WASHINGTON, June 10 ? Postmenopausal women with high levels of estradiol and testosterone are at a greatly increased risk of developing type 2 diabetes, according to data on nearly 28,000 women.
Among women enrolled in the Women's Health Study, those with high levels of plasma-free and total estradiol had a nearly 12-fold risk of developing type 2 diabetes compared with women who had the lowest levels, reported epidemiology fellow Eric L. Ding, and colleagues, of the Harvard School of Public Health.
"The results are actually quite astonishing," said Ding during a presentation at the American Diabetes Association meeting here today.
There were 123 cases of type 2 diabetes in women in the highest quintile of sex hormones, compared with 21 in the lowest quintile, and the associations between sex hormone levels and diabetes risk held up even after controlling for multiple risk factors, Ding said.
He and his colleagues conducted a prospective, nested case-control study of plasma estradiol, testosterone, sex hormone-binding globulin, and dehydroepiandrosterone sulfate (DHEAS) as predictors of type 2 diabetes.