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Heterochromia Iridis

Heterochromia Iridis

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A 20-year-old woman is noted to have one blue and one brown iris.

Key point: By definition, this individual demonstrates complete heterochromia iridis. There are varying degrees of this phenomenon, including sectoral and central heterochromia. This finding may be inherited or acquired.

Treatment: Acquired heterochromia may be caused by chronic uveitis, or (rarely) an underlying neuroblastoma. The latter etiologies should be sought and treated accordingly.

Note: Inherited heterochromia may be associated with Waardenburg syndrome (in conjunction with sensorineural deafness) or with piebaldism (in conjunction with a central forelock of white hair).

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