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Low Estrogen Linked to Knee Osteoarthritis in Women

Low Estrogen Linked to Knee Osteoarthritis in Women

ANN ARBOR, Mich., July 26 -- Possible strategies aimed at boosting levels of estradiol and one of its metabolites are being considered to help prevent osteoarthritis of the knee in women approaching menopause, a study here suggested.

Women near menopause with the lowest levels of circulating estradiol were nearly twice as likely to develop osteoarthritis of the knee over a three-year period as women with higher levels of the hormone, reported MaryFran R. Sowers, Ph.D., and colleagues, of the University of Michigan.

Similarly, women with the lowest levels of 2-hydroxyesterone, an estrogen metabolite, were at nearly three times the risk, the researchers said in the August issue of Arthritis & Rheumatism.

"There has been an ongoing debate as to whether hormone levels contribute to the pathogenesis of osteoarthritis and/or serve as a biomarker of risk for the development of osteoarthritis," the researchers said.


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