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The Role of Amyloid in Type 2 Diabetes

The Role of Amyloid in Type 2 Diabetes

How does amyloid in the pancreatic islets contribute to the development and progression of type 2 diabetes? Also, does amyloid have a direct effect on beta cells?
-- Peter Hayden, MD
    Camdenton, Mo
The deposition of amyloid in beta cells has the same effect as in other tissues. It disrupts the normal molecular relationships in these cells, which results in abnormal functioning. In addition, it causes the cells to age more quickly and to die earlier. This leads to a diminished capacity for secreting insulin.
-- Gerald Bernstein, MD
    Associate Clinical Professor of Medicine
    Albert Einstein College of Medicine
    New York

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