Despite a lower prevalence of traditional risk factors—such as hypertension and diabetes—patients with inflammatory bowel disease (IBD) have a higher incidence of stroke, said researchers at the University of Miami.1
In this retrospective cohort study, 356 patients with a diagnosis of IBD were compared with 712 matched controls. The primary outcome was the development of a cerebrovascular accident (CVA), defined as an acute neurological event accompanied by corresponding radiologic abnormality on CT and/or MRI; both ischemic and hemorrhagic events were included.
The incidence of CVA in the IBD cohort was 9.52 events per 1000 person-years, compared with 5 per 1000 person-years in the control group (P < .01). Hypertension, diabetes, and dyslipidemia were significantly more common among controls than among patients with IBD (P < .01); however, there was no significant difference in smoking status (P = .26). The odds ratio for the risk of stroke in the IBD cohort was 2.33 (95% CI [1.14 –4.72], P = .005).
The researchers suggest that premature development of atherosclerosis and hypercoagulability in patients with IBD may be responsible for the increased incidence of CVA.
1. Yarur A, Sussman D, Deshpande A, et al. Inflammatory bowel disease increases the incidence of stroke. Paper presented at: 2010 Advances in Inflammatory Bowel Diseases Conference; December 9-12, 2010; Hollywood, Florida.