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HIV-Related Oral Lesions: Clues for Early Diagnosis

HIV-Related Oral Lesions: Clues for Early Diagnosis

Oral lesions are often the harbingers of early HIV infection. They are among the most common complaints for which HIV-positive patients seek primary care and are often misdiagnosed or inadequately treated.1 More than 90% of patients with AIDS have 1 or more oral manifestations during the course of their illness.2

Common oral manifestations include candidiasis, linear gingival erythema, necrotizing ulcerative periodontitis, xerostomia, Kaposi sarcoma, herpes simplex virus lesions, aphthous ulcers, human papillomavirus (HPV)-associated warts, and hairy leukoplakia.1 Here we discuss 2 cases of young, healthy-appearing men who presented with HIV-related oral lesions.


A 30-year-old man with a 15 packyear smoking history presented for a follow-up evaluation of an asymptomatic whitish lesion on the tongue of 4 months’ duration. The lesion had not responded to oral therapy with either nystatin or fluconazole. The patient was distressed about the lesion’s appearance and his inability to remove it with a toothbrush.


Multiple, nontender, whitish, vertical striations were noted along the right lateral edge of the lesion (Figure 1). No ulcerations, vesicles, verrucae, fissures, or exanthemas were visible in the oral cavity; there was no evidence of bleeding or exudates. The physical findings were otherwise unremarkable.

A presumptive clinical diagnosis of oral hairy leukoplakia was made, and an HIV test was ordered. Histological examination of a biopsy specimen of the lesion revealed hyperkeratosis and koilocytosis without inflammation.

Results of the HIV test were positive. The CD4+ cell count was 312/μL (HIV RNA level, 27,000 copies/mL). Oral acyclovir was started, and the lesion resolved by the end of the third week of treatment.

Oral hairy leukoplakia is the classic intraoral lesion of HIV/AIDS. This entity generally manifests as a unilateral or bilateral adherent grayish white or yellowish white patch on the lateral margins of the tongue. These patches may appear as irregular folds or projections and often have a corrugated surface. The lesion can also occur on the ventral surface of the tongue but is typically flat in this region.2,3 Other possible locations include the floor of the mouth and the buccal mucosa. The lesions are usually asymptomatic, although occasionally patients may complain of soreness or burning.

Etiology and incidence. Oral hairy leukoplakia is thought to be mediated by the intense replication of the Epstein-Barr virus (EBV) and is fairly specific to the immunodeficient state caused by HIV disease. However, it has also been described in patients who are immunocompromised because of organ transplant or autoimmune disease and very rarely in those who are otherwise seemingly healthy. Oral hairy leukoplakia is almost exclusively seen in men who have sex with men. Its presence is generally a sign of moderate to severe HIV disease (with CD4+ cell counts of less than 300/μL) and can be considered a clinical marker for disease progression. AIDS can be expected to develop in up to 30% of such patients within 3 years.4,5

Diagnosis. A presumptive clinical diagnosis can be made by the history and physical examination. A thorough medical and social history will often reveal the cause of immunosuppression. Unlike candidal infection, the lesions cannot be scraped off and are also unresponsive to antifungal therapy. When the diagnosis is unclear, a biopsy can be performed. A more definitive diagnosis can be made by in situ hybridization of EBV DNA.3

Prognosis and treatment. Oral hairy leukoplakia has no malignant potential. It is generally not treated unless the patient experiences interference with speech, taste, or chewing or requests treatment for cosmesis. The disorder responds to topical retinoids or podophyllin. Oral antiviral agents, including acyclovir, zidovudine, ganciclovir, and foscarnet, may also be effective. Relapses are common once treatment is discontinued. The lesions also respond favorably during the course of highly active antiretroviral therapy, as the CD4+ cell count rises.3 Patients should be instructed to comply with regular dental and medical care regimens.


A 34-year-old man presented for a routine physical examination. He appeared healthy and had no recent history of weight loss, fever, fatigue, forgetfulness, rash, lymphadenopathy, diarrhea, or cough.

Examination of the oral mucosa revealed a friable, filiform, digitate lesion on the upper gum (Figure 2). This lesion had been present for several months and bled occasionally when he brushed his teeth.

A clinical diagnosis of HPV infection was made. Results of HIV testing were positive. The patient’s CD4+ cell count was 391/μL (HIV RNA level, 26,000 copies/mL).

Because of the concern for other sexually transmitted infections in persons with HPV infection, this patient was also tested for Chlamydia infection, gonorrhea, syphilis, and hepatitis B. He declined treatment of his oral lesion at the time of diagnosis.


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