A zoonosis is any disease-bacterial, mycotic, viral, or parasitic-that is transmissible from an animal to a human. More than 200 zoonoses have been identified. The newly emerging zoonosis that has achieved star status in the medical press is avian influenza. Another emerging threat is Nipah virus, which is transmitted from pigs to humans in the agricultural setting and causes encephalitis. But animal to human transmission of zoonoses are multimodal: from exposure to animal secretions in the agricultural setting, to transmission through insect vectors and ingestion of contaminated animal products, to more insidious routes, such as petting or being scratched or nipped at by one's pet dog, bird, cat, lizard, or other creature. A few interesting cases are presented here.