Obesity has become an unforgiving epidemic and the tip of a morbidity-mortality iceberg. This chronic disease leads to obstructive sleep apnea; type 2 diabetes, which recently tripled in prevalence1; hypertension; insulin resistance; and a host of vascular complications.
As the prevalence of obesity rises, what tools do we have in the battle against excessive weight? Remember, a weight loss of only 5% to 10% has been demonstrated to reduce complications.1
Let’s ask some key questions about weight-loss modalities in the context of obesity and type 2 diabetes:
1. Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3.0 mg of Liraglutide in weight management. N Engl J Med. 2015;373:11-22.
2. Courcoulas AP, Belle SH, Neiberg RH, et al. Three-year outcomes of bariatric surgery vs lifestyle intervention for type 2 diabetes mellitus treatment: a randomized clinical trial. JAMA Surg. 2015; Jul 1. doi: 10.1001/jamasurg.2015.1534. [Epub ahead of print]
3. Carlsson LM, Peltonen M, Ahlin S, et al. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N Engl J Med. 2012;367:695-704.
4. Gagner M. Bariatric surgery vs. lifestyle intervention for type 2 diabetes mellitus. JAMA. 2015; Jul 1. doi: 10.1001/jamasurg.2015.1542. [Epub ahead of print]
5. Siraj ES, Williams KJ. Another agent for obesity—will this time be different? N Engl J Med. 2015;373:82-83.