A 29-year-old man presented with a complaint of venereal warts and a long history of mild psoriasis, which he had treated with fluocinolone. He returned 3 months later complaining of chest congestion of 10 days' duration; it had been treated with ciprofloxacin at an urgent care facility. Physical examination revealed diffuse lymphadenopathy, and a chest film demonstrated bilateral interstitial infiltrates. A consultation with a pulmonologist led to the diagnosis of Pneumocystis carinii pneumonia and AIDS. Eight months later, the patient's psoriasis–seen here–had dramatically worsened and was resistant to treatment with coal tar solution and topical hydrocortisone.