A number of nondental conditions
may cause significant oral pain. Pain
associated with temporal arteritis is localized
to the maxillary posterior teeth, the
maxilla, or the frontal-temple region. This
pain is often associated with exquisite tenderness
of the scalp and face. The pain of
trigeminal neuralgia is typically felt in the
anterior maxillary or mandibular anterior
teeth; it radiates along the mandible toward
or into the ear on the ipsilateral side
of the trigger. Pain may remit for months
or years but is often severe when it recurs.
Burning mouth syndrome preferentially
affects postmenopausal women older
than 50 years; one half to two thirds of
patients experience spontaneous remission
within 6 to 7 years, with or without treatment.
The pain of postherpetic neuralgia is
unilateral and restricted to the affected
dermatome; it may be aggravated by mechanical
contact or chewing.
Most pain in or around the oral cavity is attributable to tooth or mucosal pathology. However, tooth or mucosal pain may also be caused by a variety of other conditions, including brain pathology; vascular inflammatory and cardiac disease; jaw infection or neoplasm; neuropathic abnormality not associated with central pathology; pathology in the neck and thoracic region; myofascial and temporomandibular joint pathology; and disease of the ear, eye, or nose, or of the paranasal sinuses, lymph nodes, and salivary glands. Accurate diagnosis is facilitated when the features of pain presentation in this region are understood.
Classification of and criteria for nondental conditions that can cause tooth pain appear in a number of sources.1-4 Clinical factors, including the patient's description of pain; its
intensity, quality, and location; what relieves or exacerbates it; and the presence (or absence) of additional symptoms (eg, dysesthesia) may help establish the diagnosis when oral examination findings are negative. Additional imaging studies may be necessary to rule out problems such as salivary or central disease.
In my 2-part series, I review some of the more significant nondental conditions that cause tooth and mucosal pain; I also address treatment options. Here the focus is on temporal arteritis (TA), trigeminal neuralgia, burning mouth syndrome, postherpetic neuralgia (PHN), vascular conditions, masticatory myofascial conditions, and salivary gland pathology. In an upcoming issue, I will discuss oral cancer, maxillary sinus disease, and nonmalignant disorders of the oral mucosa.
The approximate annual incidence of TA varies by region but was reported in one study to be 4.1 cases per 100,000 persons.5 The typical patient is older than 50 years and looks and feels quite ill at presentation.
Dental pain associated with TA is usually localized to the maxillary posterior teeth (the first or second molar) or the maxilla, including the palate. Pain may also be perceived in or radiate to the frontal-temple region. The intensity of pain is described as moderate to severe and the quality as throbbing or aching/throbbing. It may be bilateral or unilateral. Pain may develop slowly or suddenly but, once established, it is unremitting.6
Chewing may worsen tooth pain as well as general pain—hence the presumption of a dental cause. However, in contrast to pain of pulpal (ie, dental) origin, the pain of TA is often associated with exquisite tenderness (hypersensitivity) of the scalp and face. Patients often report that hair combing or very light touching of the frontal-temple area is painful. Patients may also present with a number of more generalized symptoms, such as malaise or low-grade fever, that are not typically associated with dental pain (unless there is frank infection and cellulitis). There may also be ocular symptoms.
Additional factors that help establish the diagnosis include a significantly elevated erythrocyte sedimentation rate and hardness of the temporal artery on palpation. Temporal artery biopsy confirms the diagnosis. Early diagnosis is crucial because vision loss may result from delayed treatment.7 Treatment consists of high-dose corticosteroids (40 to 60 mg/d) with rapid taper over 7 to 10 days. In some cases, long-term therapy is required.
The pain of trigeminal neuralgia is typically felt in the anterior maxillary or mandibular anterior teeth (within the second and third division of the fifth cranial nerve) or, if the patient is edentulous, in the attached mucosa overlying the alveolar bone or a healed extraction site.8 Less frequently, it is perceived in the posterior teeth.
This pain, which is described as electrical, shocklike, or stabbing, is triggered by light touch and typically radiates along the mandible toward or into the ear on the ipsilateral side of the trigger or, if perceived in the maxillary region, superiorly into the eye or the maxillary sinus. The pain may be severe or excruciating. Unlike the pain of TA, however, the pain of trigeminal neuralgia is episodic, with paroxysms that last for seconds to minutes. A more generalized low-grade pain sometimes follows the severe attack. The severe paroxysmal pain is followed by a variable pain-free interval. Although pain may sometimes remit for months or years, recurring pain may be incapacitating.
Often, patients think that trigeminal neuralgia represents a dental problem because touching a tooth or adjacent mucosa in the trigger zone will initiate the paroxysm. Paroxysms can also be triggered by chewing or drinking, presumably because of the manipulation of the trigger point during these activities. However, in contrast to a patient with tooth pathology, a patient with trigeminal neuralgia often (but not always) reports an additional trigger on the external face (nose, lip, or cheek), so that touch or manipulation of an extraoral area during showering, smiling, shaving, or applying makeup also triggers pain.
Unlike patients with TA, those with trigeminal neuralgia do not have malaise or fever. Laboratory results are normal. A trial of an anticonvulsant medication such as carbamazepine or gabapentin may be useful in establishing the diagnosis.9 In a patient whose pain does not respond to medication, or who reports additional sensory abnormality, such as facial numbness or tingling, additional evaluation should include gadolinium-enhanced MRI to rule out central tumor. In a person with neuralgia who is younger than 45 years, consider multiple sclerosis and brain tumor in the differential diagnosis.10
BURNING MOUTH SYNDROME
This condition preferentially affects postmenopausal women older than 50 years.11 Pain may involve the palate, tongue, lips, attached mucosa, oropharynx, or a combination of these. Pain is not typically perceived in the teeth, but severity is comparable to that of mild to moderate toothache. Involvement is usually bilateral, and there may be associated dysgeusia (alteration in taste).
The differential includes such conditions as tongue muscle hyperactivity; oral candidiasis; salivary hypofunction; Sjgren syndrome; denture-related causes; hematinic deficiency states (iron, vitamin B, and folate deficiencies); allergic reactions or reactions to chemical irritants; medication side effects; peripheral neuropathy; and a variety of intraoral diseases, such as migratory glossitis or lichen planus.12 Less likely, but still possible, is undiagnosed or poorly controlled diabetes, a psychological disorder, malignancy, or central pathology. If the burning is unilateral and is associated with dysesthesia (eg, numbness or tingling) in the absence of trauma, consider a neoplasm such as adenocystic carcinoma of the posterior tongue or the vestibule, PHN (see below), or ventral pontine infarction.13
Once these conditions have been ruled out, moderate relief of symptoms can be obtained with clonazepam, 0.25 to 2 mg/d. The combination of gabapentin and clonazepam is also effective.14 Some patients respond to topical anesthetics, such as lidocaine (2%) or dyclonine hydrochloride (1%). I have found that having patients rinse with doxepin elixir every 4 to 6 hours and swallow the last dose at bedtime sometimes relieves pain. About one half to two thirds of patients will experience spontaneous pain remission within 6 to 7 years, with or without treatment. Psychological intervention may also be helpful.15
In elderly patients who have PHN involving the face, the condition is typically localized to the first division of the fifth cranial nerve. Some patients experience significant pain in the region of initial involvement several months after the original infection has subsided. Patients describe this chronic pain as moderate to severe and burning.16 There may be dysesthesia, such as facial itching,
or other unusual sensations involving the intraoral mucosa (eg, the
sensation that something is stuck between the teeth). Pain is often exacerbated by mechanical contact. Intraoral pain, when present, is also constant and is perceived as arising in the mucosa or teeth; it may be aggravated by chewing.
Unlike the pain of burning mouth syndrome, the pain of PHN is unilateral and restricted to the appropriate dermatome. The history is likely to include a previous vesicular outbreak on the ipsilateral side (Figure 1). However, if the primary lesions occur in the mouth with minimal facial involvement (a rarer variation that affects the second and third division of the fifth cranial nerve), the patient may not be aware of the connection between the postzoster pain and the original episode. Hence, it is important to ask whether the current pain was preceded by an eruption of multiple painful intraoral vesicles that lasted 14 to 21 days.
Another herpetic condition that causes oral (including tooth) pain and dysesthesia is recurrent intraoral herpes.17 The clinical presentation of primary herpes stomatitis and the secondary recurrent lip lesion that typically follows the initial infection are familiar. However, the characteristic extraoral lesion may occur in the mouth as well (Figure 2). With intraoral expression of the disease, pain is also described as burning, but it occurs within a well-localized region of attached gingival tissue around a tooth or teeth, or on the palate. Generalized facial pain located ipsilateral to the lesions is often preceded by a sensory prodrome that may include mild to moderate tooth pain that typically persists only during the phase of vesicular eruption (7 to 10 days).
Therapeutic options for PHN include systemic antiviral medication (acyclovir or famciclovir) and tricyclic antidepressants (amitriptyline or nortriptyline, 10 to 50 mg/d).18 Topical capsaicin (applied as a cream, 0.025% or 0.075% tid) may also be effective. The combination of tricyclic antidepressants and antiviral medication, when used during the initial zoster episode, may reduce the risk of PHN.19
1. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia. 1988;8(suppl 7):1-96.
2. Merskey H, Bogduk N, eds. Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Chronic Pain Terms. 2nd ed. Seattle: International Association for the Study of Pain; 1994.
3. Okeson JP, ed. Orofacial Pain: Guidelines for
Assessment, Diagnosis, and Management. Chicago; Quintessence Publishing; 1996.
4. Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.
J Craniomandib Disord. 1992;6:301-355.
5. Bustamante Maldonado E, Mari Alfonso B, Monteagudo Jimenez M, et al. Analysis of a series of 55 patients with biopsy proven giant cell temporal arteritis. Ann Med Interna. 2004;21:473-476.
6. Diamond S, Dalessio DJ. The Practicing Physician's Approach to Headache. 4th ed. Baltimore: Williams & Wilkins; 1996.
7. Ward TN, Levin M. Headache in giant cell arteritis and other arteritides. Neurol Sci. 2005;26(suppl 2):S134-S137.
8. Burchiel KJ, Burgess JA. Differential diagnosis and management of orofacial pain. In: Tollison CD, Satterthwaite JR, Tollison JW, eds. Handbook of Pain Management. 2nd ed. Baltimore: Williams & Wilkins; 1994.
9. Burchiel KJ, Louw D. In: Rakel RE, ed. Conn's Current Therapy. 51st ed. Philadelphia: WB Saunders Co; 1999:947-950.
10. Eller JL, Raslan AM, Burchiel KJ. Trigeminal neuralgia: definition and classification. Neurosurg Focus. 2005;18:E3.
11. Lamey PJ, Lamb AB. Lip component of burning mouth syndrome. Oral Surg Oral Med Oral Pathol. 1994;78:590-593.
12. Grushka M, Sessle BJ. Burning mouth syndrome. Dent Clin North Am. 1991;35:171-184.
13. Reutens DC. Burning oral and mid-facial pain in ventral pontine infarction. Aust N Z J Med. 1990;
14. Grushka M, Epstein JB, Gorsky M. Burning mouth syndrome. Am Fam Physician. 2002;65:
15. Grinspan D, Fernandez Blanco G, Allevato MA, Stengel FM. Burning mouth syndrome. Int J Dermatol. 1995;34:483-487.
16. Barrett AP, Katelaris CH, Morris JG, Schifter M. Zoster sine herpete of the trigeminal nerve. Oral Surg Oral Med Oral Pathol. 1993;75:173-175.
17. Glick M. Clinical aspects of recurrent oral herpes simplex virus infection. Compend Contin Educ Dent. 2002;23(7 suppl 2):4-8.
18. Aguggia M. Typical facial neuralgias. Neurol Sci. 2005;26(suppl 2):S68-S70.
19. Johnson RW. Pain following herpes zoster: implications for management. Herpes. 2004;11:63-65.
20. Delcanho RE, Graff-Radford SB. Chronic paroxysmal hemicrania presenting as toothache.
J Orofac Pain. 1993;7:300-306.
21. Edvinsson L, Uddman R. Neurobiology in primary headaches. Brain Res Brain Res Rev. 2005;48:
22. Rozen TD. Cluster headache: diagnosis and treatment. Curr Pain Headache Rep. 2005;9:135-140.
23. Reeh ES, elDeeb ME. Referred pain of muscular origin resembling endodontic involvement. Case report. Oral Surg Oral Med Oral Pathol. 1991;71:
24. Ohrbach R, Burgess J. Temporomandibular disorders and craniofacial pain. In: Rakel RE, ed. Conn's Current Therapy. 51st ed. Philadelphia: WB Saunders Co; 1999:997-1002.
25. Ohrbach R, Dworkin SF. Five-year outcomes in TMD: relationship of changes in pain to changes in physical and psychological variables. Pain. 1998;74:
26. Said-Al-Naief N, Ivanov K, Jones M, et al. Granular cell tumor of the parotid. Ann Diagn Pathol. 1999;3:35-38.
27. Zbar AP, Hill AD, Shering SG, et al. A 25 year review of parotid surgery. Ir Med J. 1997;90:228-230.