Answer: B. Renal disease. Cryoglobulinemia refers to monoclonal or mixed polyclonal immunoproteins that precipitate out of blood when it is cooled below body temperature. The condition can develop when immune complexes with HCV particles deposit in vascular walls, causing vasculitis, chronic stimulation of B-lymphocytes and increased risk for B-cell non-Hodgkin lymphoma.2 HCV-related cryoglobulinemia commonly presents at Meltzer Triad (purpura, myalgia, and arthralgia). Other signs of the condition include chronic leg ulcers, weakness, and peripheral neuropathy.2
2. A 55-year-old man with chronic HCV has new-onset hypertension. Which of the following extrahepatic manifestations of HCV should not be considered as a possible cause of his elevated blood pressure?
C. Lichen planus
D. Membrane proliferative glomerulonephritis