Answer: B. False. People with chronic HCV may have up to 70% increased risk for T2DM, compared to those without HCV.3 While the precise mechanism underlying the vulnerability remains unknown, possibilities include the effect of HCV- related fibrosis and cirrhosis on insulin resistance; a direct effect of the virus on inflammatory cytokines; and the dual impact of obesity and HCV on insulin signaling.2 A key part of management for T2DM in HCV infection includes weight reduction and exercise, along with antihyperglycemics when needed.2
4. Which of the following statements is true regarding chronic HCV and B-cell non-Hodgkin lymphoma?
A. Eliminating HCV infection eliminates the increased risk for virus-associated B-cell non-Hodgkin lymphoma
B. Successfully treating HCV can cause regression of low-grade lymphomas
C. Simultaneous treatment of active HCV and chemotherapy for aggressive B-cell lymphomas is associated with worse prognosis
D. Both A and C