Patients with hepatitis C virus (HCV)-related cirrhosis who are coinfected with human immunodeficiency virus (HIV) show similar improvements in liver function scores after achieving undetectable serologic viral response for 12 or more weeks after the end of treatment (SVR12).
The first study to provide comparative results of liver function changes after response to direct-acting antiviral (DAAs) agents between patients with and without HIV infection in a large cohort shows liver function improved in more than half of patients in each cohort. The results were published in the January 2019 issue of Journal of Viral Hepatitis.
“From the start of DAA treatment to the date of SVR12 achievement, HIV/HCV-coinfected and HCV-monoinfected patients with cirrhosis show similar rates of recovery in liver function parameters,” stated the researchers, led by Juan Macias of the Infectious Diseases and Microbiology Unit of the Hospital University of Valme in Seville, Spain. “In addition, the frequencies of overall liver function, as measured by Child-Pugh-Turcotte (CPT) and MELD scores as well as by clinical outcome, improvement, and worsening after responding to DAA therapy are similar in patients with HCV-related cirrhosis with and without HIV coinfection.”
Advanced fibrosis and cirrhosis are more frequent among HIV/HCV-coinfected patients than among HCV-monoinfected patients, and liver decompensation and poor overall survival are more common in coinfected patients.