How do you like your M&Ms? All one color or do you like the “mix and match” approach? Most of us like to mix and match the colors as we plop them in our mouths. Those of us with a little OCD may just eat one color at a time. And yes, there is a vaccine connection to be made.
When it comes to vaccines that require more than one dose and more than two manufacturers produce a similar product, clinicians usually have the choice to mix and match. Some examples: there are two companies marketing rotavirus vaccines, a different two making pertussis vaccines, and five companies producing flu vaccines.
Let’s imagine a flu scenario: Flu-vaccine-naïve children under the age of 9 years need two doses of flu vaccine separated by 30 days. Assume you have an 8-year-old in your office who received his first ever flu vaccine 5 weeks earlier. He received a dose of quadravalent Fluzone. You do not have any quadravalent Fluzone in your office, but do have the below listed vaccines.
1. Which of the following would NOT be appropriate to give him?
A. Quadravalent Flumist (assume it is back on the market and ACIP approved)
B. Trivalent Fluviran
C. Quadravalent Flulaval
D. Trivalent Flublok
E. Any of the above would be fine to use