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ISTANBUL, Turkey -- Cisplatin-Navelbine (vinorelbine) reduced mortality in fully resected non-small cell lung cancer (NSCLC), according to a meta-analysis reported here.

ESMO: Cisplatin-Navelbine Duo Shows Survival Edge in NSCLC

ISTANBUL, Turkey -- Progression-free survival is prolonged by 10% in men with locally advanced prostate cancer who receive both radiation and hormone therapy, according to a large meta-analysis.

ESMO: Radiation Plus Hormone Therapy Is Prostate Cancer Plus

ISTANBUL, Turkey -- A blood test may be able to distinguish between a malignancy in the lung and a benign pulmonary pathology, researchers reported here.

ESMO: Blood Test May Screen for Lung Cancer

ATLANTA ? With a new class of drugs, researchers are on the trail of killer receptors on the surface of cancer cells.

ASCO: New Drug Class Triggers Tumor Cell Death

This 13-year-old boy presents with hyperpigmented skin on his neck. He is 66.75 inches and weighs 232 pounds.

This 13-year-old boy presents with hyperpigmented skin on his neck. He is 66.75 inches and weighs 232 pounds. Your suspicion?

Clinical Topics

13-year-old With Hyperpigmented Rash

A 76-year-old woman seeks your attention for an asymptomatic “red spot” on her neck. She has a history of multiple non-melanoma skin cancers.

Squamous cell carcinoma in situ (Bowen  disease)

Lichenoid keratosis (an inflammatory variant of seborrheic keratosis)

A 76-year-old woman seeks your attention for an asymptomatic “red spot” on her neck. What does this look like to you?

What's This "Red Spot"?

The mother of a 10-year-old boy brings him in for evaluation of his moles (which are all benign). During the visit, the mother asks about the lesions on the first 2 knuckles of his right hand; she initially noticed them several months earlier. The boy is otherwise healthy.

White Knuckles

A 32-year-old man presents with dysphagia to solid foods. His symptoms have increased in frequency during the past 6 months. He has taken to eating much more slowly and needs water to help swallow food. His history is remarkable for seasonal allergies, for which nasal fluticasone is prescribed. He undergoes an upper endoscopy, which demonstrates diffuse rings, longitudinal furrows, and white plaques. Esophageal biopsies reveal dense eosinophilia throughout.

A. Start swallowed topical corticosteroids

B. Refer to allergist for skin prick testing

C. Begin treatment with an acid suppressant

These endoscopic findings help explain worsening dysphagia in a 32-year-old man. Esophageal biopsies prove positive for eosinophilia. How would you proceed? 

Esophageal Rings, Furrows, and Plaques: What Next?

Acromegaly was diagnosed in a 36-year-old woman who presented with loss of vision in the right eye that had initially involved the peripheral field. MRI scans of the brain revealed a 6 × 6 × 4-cm sellar mass with suprasellar and parasellar extension encasing the right cavernous sinus and carotid artery.

A. Excess growth hormone production from the pituitary gland as a result of a functional adenoma is the most common cause.

B. It remains undiagnosed for up to 10 years on average.

C. The diagnostic test of choice is an oral glucose tolerance test.

D. End-organ manifestations (eg, arthropathy, cranial nerve palsies, diabetes) contribute to overall mortality increase.

Acromegaly was diagnosed in a 36-year-old woman who presented with loss of vision in the right eye that had initially involved the peripheral field. Which statement about acromegaly is NOT true?

Acromegaly: A Pop Quiz

A 66-year-old woman had a mildly pruritic rash on the buttocks, lower back, abdomen, and upper posterior thighs. The eruption had been present for approximately 18 months.

A 66-year-old woman had a mildly pruritic rash on the buttocks, lower back, abdomen, and upper posterior thighs. The eruption had been present for approximately 18 months. Your diagnosis?

“Swimsuit Area” Rash: Your Dx?

Rabiya Tuma, Ph.D.

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