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Depression is a major barrier to HIV care. But depression treatment can significantly reduce depressive severity--and improve HIV outcomes. Details here.

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An increasing number of older AIDS patients are starting antiretroviral therapy. Maximum survival benefit is realized when ART is initiated when CD4 counts are high--regardless of the patient's age, according to a new study.

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Clinically significant drug interactions involving antiretroviral agents have been reported in 30% to 40% of HIV-positive patients in the USA. However, this study finds that just a few therapeutic groups are responsible for most of the interactions detected.

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Previous studies have established that early treatment of HIV dramatically reduces the odds of spreading the infection to a sexual partner. The START trial provides evidence that early therapy benefits a patient's own health.

Screening for tobacco use and strategies for quitting are important considerations for patients with HIV, since infected adults are more likely to smoke -- and less likely to quit -- than those who are uninfected.

The antiviral future holds great promise for people living with HIV: better-tolerated, less toxic, drugs are about to come to market, and we are about to see the introduction of drugs from 1 or 2 new classes.