• Heart Failure
  • Cardiovascular Clinical Consult
  • Adult Immunization
  • Hepatic Disease
  • Rare Disorders
  • Pediatric Immunization
  • Implementing The Topcon Ocular Telehealth Platform
  • Weight Management
  • Monkeypox
  • Guidelines
  • Men's Health
  • Psychiatry
  • Allergy
  • Nutrition
  • Women's Health
  • Cardiology
  • Substance Use
  • Pediatrics
  • Kidney Disease
  • Genetics
  • Complimentary & Alternative Medicine
  • Dermatology
  • Endocrinology
  • Oral Medicine
  • Otorhinolaryngologic Diseases
  • Pain
  • Gastrointestinal Disorders
  • Geriatrics
  • Infection
  • Musculoskeletal Disorders
  • Obesity
  • Rheumatology
  • Technology
  • Cancer
  • Nephrology
  • Anemia
  • Neurology
  • Pulmonology

Apple Core Lesion


A 48-year-old woman was hospitalized for acute-onset abdominal pain. She had a history of adult-onset Still disease and severe osteoarthritis. She had been taking 650 mg of aspirin every 4 hours to relieve her arthritis pain and fevers.

A 48-year-old woman was hospitalized for acute-onset abdominal pain. She had a history of adult-onset Still disease and severe osteoarthritis. She had been taking 650 mg of aspirin every 4 hours to relieve her arthritis pain and fevers.

The patient had tenderness in the right upper quadrant, without signs of peritonism. A CT scan with contrast of the abdomen and pelvis demonstrated an apple core lesion (A). Colonoscopy revealed an ulcerated mass in the ascending colon, which strongly suggested malignancy (B). However, a biopsy specimen of the lesion showed only inflammatory changes with areas of ulceration (C).

At our advice, the patient-who was taking 16 medications in total-discontinued aspirin therapy. Thereafter, the patient’s health improved and a diagnosis of NSAID-induced colitis was made. CT (D) and colonoscopy (E) done 6 months later showed complete resolution of the lesion. Our patient is currently controlling her arthritic joint pain with acetaminophen.

The radiological hallmarks of the classic colonic apple core lesion are short, sharply defined regions of annular colonic narrowing with overhanging margins; ulcerated mucosa; and eccentric, irregular lumen. An apple core lesion can have a number of causes, the most serious being malignant neoplasm. The differential diagnosis for colitis is wide and includes inflammatory bowel disease (Crohn disease and ulcerative colitis); diverticulitis; and infective, microscopic, and drug-related colitis.

It is becoming increasingly clear that NSAIDs, including salicylates, may adversely affect the colon as well as the upper GI tract.1,2 They may cause nonspecific colitis or exacerbate a preexisting colonic disease. Presenting features include abdominal pain, weight loss, diarrhea (bloody or nonbloody), and iron deficiency anemia. Colonoscopy may show inflammation, ulceration, or stricture. Histology often shows a nonspecific colitis or pattern similar to that of ischemic colitis.3

The pathogenesis of NSAID-induced colitis is controversial. Local and/or systemic effects of NSAIDs on mucosal cells might lead to an increased intestinal permeability, a prerequisite for colitis.4 NSAID-induced colitis is treated by discontinuation of the offending medication if possible and therapy with either sulfasalazine5 or metronidazole.6 Surgery is often indicated in cases of life-threatening complications or intractable symptoms.7




Margolius DM, Cataldo TE. Nonsteroidal anti-inflammatory drug colopathy mimicking malignant masses of the colon: a report of three cases and review of the literature.

Am Surg.



Aftab AR, Donnellan F, Zeb F, et al. NSAID-induced colopathy. A case series.

J Gastrointestin Liver Dis.



Püspök A, Kiener HP, Oberhuber G. Clinical, endoscopic, and histologic spectrum of nonsteroidal anti-inflammatory drug-induced lesions in the colon.

Dis Colon Rectum.



Bjarnason I, Smethurst P, Macpherson A, et al. Glucose and citrate reduce the permeability changes caused by indomethacin in humans.




Bjarnason I, Middleton K. Effect of polymer coating on faecal recovery of ingested 5-amino salicylic acid in patients with ulcerative colitis.




Bjarnason I, Hayllar J, Smethurst P, et al. Metronidazole reduces inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy.




Faucheron JL, Parc R. Non-steroidal anti-inflammatory drug-induced colitis.

Int J Colorectal Dis.


Related Videos
New Research Amplifies Impact of Social Determinants of Health on Cardiometabolic Measures Over Time
Overweight and Obesity: One Expert's 3 Wishes for the Future of Patient Care
Donna H Ryan, MD Obesity Expert Highlights 2021 Research Success and Looks to 2022 and Beyond
"Obesity is a Medically Approachable Problem" and Other Lessons with Lee Kaplan, MD, PhD
Related Content
© 2024 MJH Life Sciences

All rights reserved.