Darkened Epidermis

News
Poll

A 31-year-old woman presents with ongoing weakness and malaise and says her skin seems to be getting darker without exposure to the sun. Your Dx?

A 31-year-old woman complains of episodes of weakness, upper abdominal discomfort, and nausea for the past 6 months. She also states that her skin appears to be getting darker even though she spends no more time in the sun than usual. Her hand is seen on the right in the Figure next to that of her treating physician.

 

What's your diagnosis?

A. Whipple's disease
B. Cushing's disease (due to elevated ACTH)
C. Haemochromatosis
D. Addison's disease

Newsletter

Enhance your clinical practice with the Patient Care newsletter, offering the latest evidence-based guidelines, diagnostic insights, and treatment strategies for primary care physicians.

Subscribe Now!
Related Content
Dupilumab Sustains Long-Term Reduction of S. aureus in People with AD: Daily Dose / image credit: ©New Africa/AdobeStock

Dupilumab Sustains Long-Term Reduction of S. aureus in People with AD: Daily Dose

Sydney Jennings
July 16th 2025
Article

Your daily dose of the clinical news you may have missed.

The Weekly Dose: Clinical Updates on Cancer Detection, Cognitive Screening, CVD Prevention, Atopic Dermatitis Treatment

The Weekly Dose: Clinical Updates on Cancer Detection, Cognitive Screening, CVD Prevention, Atopic Dermatitis Treatment

Sydney Jennings
July 8th 2025
Podcast

Discover essential clinical insights on Alzheimer disease screening in primary care, eczema treatments, and the latest in cancer detection and diet impacts on CHD risk.

©Apogee Therapeutics

Apogee Hopes Raised by Phase 2 Data for APG777 to be a Best-In-Class for Atopic Dermatitis

Grace Halsey
July 7th 2025
Article

The investigational IL-13 inhibitor showed topline EASI-75 of 66.9% and reduced injection frequency in part A of the APEX phase 2 clinical trial.

Weekly Dose: A Roundup of Top Stories for Primary Care Physicians

Weekly Dose: A Roundup of Top Stories for Primary Care Physicians

Sydney Jennings
May 7th 2025
Podcast

PODCAST: Listen to our first episode for new research on bacterial vaginosis, a new treatment option for chronic urticaria, and more.

Roflumilast Cream 0.15% Receives Strong Recommendation for Atopic Dermatitis in AAD Guideline Update / image credit ©Arcutis Biotherapeutics

Roflumilast Cream 0.15% Receives Strong Recommendation for Atopic Dermatitis in AAD Guideline Update

Grace Halsey
June 26th 2025
Article

Roflumilast 0.15% is the only 1 of 4 newly evaluated branded topical therapies to receive the Academy's strong recommendation for AD management in adults.

Investigational Respegaldesleukin Drives Early EASI Improvement and Symptom Relief in Adults with Moderate-to-Severe Atopic Dermatitis

Investigational Rezpegaldesleukin Drives Early EASI Improvement and Symptom Relief in Adults with Moderate-to-Severe Atopic Dermatitis

Grace Halsey
June 25th 2025
Article

In the phase 2b trial, the IL-2 pathway agonist and Treg proliferator demonstrated a strong dose-dependent biological response across 3 treatment arms vs placebo.

© 2025 MJH Life Sciences

All rights reserved.