Diet and Exercise Will Not Sustain Weight Loss in Obesity

The metabolic pathology that underlies obesity must be addressed through medication or bariatric surgery or significant weight loss will be transient.

Diet and exercise alone are not sufficient to promote meaningful, sustained weight loss in people with obesity, according to Caroline Apovian, MD. It is the underlying pathology in obesity that causes faulty hormonal signals which must be addressed and requires pharmacologic management and not infrequently, surgery.


Caroline M. Apovian, MD, is professor of medicine and pediatrics, in the section of endocrinology, diabetes, and nutrition at Boston University School of Medicine and the director of the Center for Nutrition and Weight Management at Boston Medical Center.

Dr. Apovian is an internationally recognized authority on nutrition, metabolism, and obesity medicine and has been in the field for nearly 3 decades.

Her current research interests are in: weight loss/gain and its effects on adipose tissue metabolism and inflammation, obesity and cardiovascular disease (CVD), resolution of diabetes and CVD in the bariatric surgery population, disparities in the treatment of obesity in underserved populations and novel pharmacotherapeutic agents for the treatment of obesity.