Early differentiation of epileptic from nonepileptic seizures is important. Clues that suggest epilepsy are a history of febrile seizures (particularly if prolonged), past brain injury from trauma or infection, and epilepsy in first-degree relatives.
Early differentiation of epileptic from nonepileptic seizures is important. Clues that suggest epilepsy are a history of febrile seizures (particularly if prolonged), past brain injury from trauma or infection, and epilepsy in first-degree relatives. Nonepileptic events that can resemble epileptic seizures include night terrors, benign sleep movements, breath-holding spells, gastroesophageal reflux symptoms, syncope, and migraine. In addition, conversion disorder can manifest as psychogenic nonepileptic seizures. If the seizure events are reasonably frequent, a long-term electroencephalogram that records the habitual attacks helps provide diagnostic certainty.
It can be difficult to determine whether unusual, paroxysmal behavior represents a seizure or a nonepileptic event. Patients with sudden flailing movements or unresponsive staring may, in fact, be experiencing psychogenic events. Other types of pathological spells, such as syncope and migraine, can also be mistaken for epileptic seizures. When epilepsy is incorrectly diagnosed in these patients, unnecessary seizure medication is likely to be prescribed, and correct diagnosis and treatment is delayed. It is also the case that epileptic seizures can be subtle and difficult to recognize. Inattentive staring may be attributed to attention deficit disorder but may, in fact, be due to either absence or complex partial seizures. An orderly approach to the differential diagnosis of paroxysmal events is the best way to avoid misdiagnosis. A careful, detailed history and physical examination supplemented by an electroencephalogram (EEG) will, in most cases, result in a correct diagnosis.
Epileptic seizures are paroxysmal, abnormal behaviors caused by excessive, hypersynchronous firing of neurons in the brain. Most seizures arise in the cerebral cortex, although subcortical structures can also generate seizures.1,2 The mechanism underlying hypersynchrony varies with epilepsy type but, in general, can be explained as an imbalance between excitatory and inhibitory input. For example, if a particular population of excitatory brain cells is damaged, the surviving cells may sprout and connect to more than their usual number of downstream neurons. Each upstream cell now “controls” a large group of downstream cells. So when the upstream cell fires, it can “synchronize” more downstream cells.3
Epilepsy is a disorder marked by recurrent, spontaneous seizures. The incidence of epilepsy is highest in early childhood and peaks again late in life.4 The peak in childhood reflects a combination of genetic predisposition and various brain pathologies evident in the young. In the elderly, the increased incidence represents the accumulated insults our brains sustain from such things as vascular disease and trauma. When epilepsy is attributed to a brain abnormality (eg, mental retardation, cerebral palsy, malformation), it is classified as “symptomatic.” Epilepsy is considered “idiopathic” when there is no recognized brain abnormality.5
Seizures are often the result of some acute, temporary perturbation of the brain’s “environment.” For example, a high fever, hypoglycemia, hyponatremia, hypoxia, and exposure to stimulant drugs of abuse are some of the precipitants of “acute reactive seizures.” When there is an apparent acute precipitant, the seizure is not considered diagnostic of epilepsy.6
The risk of recurrence within 2 years after a first-time, unprovoked seizure is approximately 35% to 40%.7 Increased risk of recurrence is associated with factors such as a remote, symptomatic cause (eg, brain injury); abnormal EEG; and seizure during sleep. Treatment with antiepileptic medication reduces the risk of a recurrence after a first seizure, but there is little evidence that treatment prevents the later development of epilepsy.8
Prolonged seizures can cause brain injury, but epidemiologic studies have not provided evidence that prolonged first seizures in otherwise healthy persons increase the risk of subsequent seizures.9 Furthermore, the number of seizures that occur before treatment is initiated is not necessarily associated with a greater likelihood of medical intractability.10 Seizure frequency and whether the seizures are generalized or partial have stronger predictive power. Therefore, little advantage is gained by treating first-time seizures, whether they are provoked by an identified acute insult or they occur out of the blue. There are certainly social consequences after a first seizure, so in some cases physicians and their patients opt to treat after a first event.11 The rationale for treating persons with recurrent seizures is that treatment will ameliorate seizure recurrence.
Most often, seizure history obtained from the patient or family members and the physical findings will lead the physician to suspect epilepsy. For example, a history of febrile seizures (particularly if prolonged) is a well-recognized risk factor for the development of temporal lobe epilepsy caused by mesial temporal sclerosis.12,13 An additional helpful clue from the history is a past brain injury from trauma or infection. It is generally understood that relatively remote trauma of a minor degree confers very little risk, but prolonged loss of consciousness or a penetrating head injury are significant risk factors for seizure episodes.14,15 A family history is important, because epilepsy in first degree relatives is another risk factor.
Physical examination findings that indicate an abnormality of brain function provide further evidence of an increased likelihood of seizures. They also help classify epilepsy as either symptomatic or idiopathic. For example, mental retardation, cerebral palsy, or the presence of neurocutaneous lesions is noteworthy. Magnetic resonance imaging (MRI) and computed tomography (CT) may demonstrate a structural brain abnormality. On the other hand, functional imaging studies, such as positron emission tomography (PET) and single photon emission CT (SPECT), give little help distinguishing between epileptic and nonepileptic events.
Certain circumstances can erroneously heighten suspicion of seizures by the patient, caregiver, and physician. Benign or at least nonepileptic behaviors may be mistakenly identified as seizures or described in rather dramatic terms. Table 1 provides a brief overview of nonepileptic events that mimic specific seizure types that occur particularly in children.
Parents of children who have health challenges that may include previous seizures may be very sensitive to any perceived abnormality in the child’s health. Benign events, such as hypnic jerks, may prove very frightening to the parents of a child who recently suffered a febrile seizure. A child with autism may have stereotyped movements that convince a concerned parent that the child is having seizures. Munchausen syndrome and Munchausen syndrome by proxy also may present as seizures.16,17
Nonepileptic seizures are behavioral events that resemble epileptic seizures but are not caused by abnormal, hypersynchronous neuronal discharges in the brain. The term “pseudoseizure” is discouraged, since the events themselves are real and disabling. Nonepileptic events can be caused by psychological disorders, or they can be manifestations of other pathological or physiological neurological conditions.
Alternating hemiplegia. This is characterized by repeated bouts of dystonic posturing accompanied by nystagmus. Hemiplegia can occur on either side or bilaterally. It occurs in the presence of developmental regression and persistent developmental delay. Onset is usually during infancy. The condition has been variously attributed to a migrainous mechanism, epilepsy, and movement disorder. The underlying cause has been linked to mitochondrial dysfunction, channelopathies, and small vessel disease. The calcium channel blocker flunarizine has been used in treatment, as has topiramate.18,19
Benign sleep movements. Benign myoclonus or hypnic jerks often occur shortly after falling asleep. Movements during rapid eye movement sleep also may be mistaken for seizures. Correct identification of these events often will allay the anxiety of patients and caregivers. However, if a child has experienced a seizure (eg, a febrile convulsion) previously, parents may be hypervigilant. Asking the parents to record a video of such movements may be helpful.20
Breath-holding spells (BHS). These spells commonly begin between the ages of 6 and 18 months. They are characterized by hard crying in response to injury or anger and breath-holding, stiffening, and cyanosis (or sometimes pallor) followed by brief loss of muscle tone and consciousness.
Pallid BHS are a type of syncope. They are more likely to occur in reaction to an event causing injury, pain, or emotional distress.21 Some children hold their breath on inspiration before getting the first cry out. Others hold their breath in expiration. They usually stop the behavior by age 5 or 6 years. A family history of BHS is common.
BHS are generally benign but can occasionally provoke acute reactive seizures, presumably caused by transient cerebral hypoxia in much the same way syncope can provoke acute seizures.22 Recognition depends on taking a careful history that looks for consistent initial crying and cyanosis or pallor early in the attack. Treatment for routine BHS consists of reassurance. Some evidence suggests that iron supplementation helps some children.23
Gastroesophageal reflux. Symptoms associated with gastroesophageal reflux may be mistaken for seizures. Infants may have stiffening and crying episodes suggestive of infantile spasms. Older children and adults, particularly if they are cognitively impaired and not able to communicate well, may have reflux-related pain leading to stiffening episodes that are reminiscent of tonic seizures, or they may have sudden behavior changes suggesting partial seizures. Abnormal posturing in patients with gastroesophageal reflux is often referred to as Sandifer syndrome.24,25
Syncope. The distinction between epileptic seizures and syncope can be particularly challenging. Transient loss of consciousness-particularly if accompanied by body stiffening- can suggest seizures, but positive motor signs are common in syncope. At the same time, transient cerebral hypoperfusion occurring during syncope can cause an acute reactive seizure (convulsive syncope).
Features suggesting syncope include preceding light-headedness, sweating, pallor, prolonged standing, sudden changes in posture-from lying down to sitting or standing- and precipitation by vagal stimuli, such as micturition. Conversely, typical aura (eg, epigastric rising sensation, dj vu), postictal delirium, and focal physical features, such as head turning, are suggestive of seizure.26 An EEG showing epileptiform discharges or postictal slowing can help confirm the diagnosis. An electrocardiogram (ECG) revealing an arrhythmia, a long QT syndrome, or a positive tilt table test suggests syncope.27,28
There are also rare cases in which a seizure provokes asystole. When such cases are recognized, the insertion of a pacemaker is often recommended.29
Conversion disorder. Conversion disorders can manifest as psychogenic nonepileptic seizures (PNES) in adults and children. A history of significant social stresses should alert a clinician to the possibility of PNES. Some apparent secondary gain usually will be associated with the spells, although in conversion disorder, the patient is not consciously producing the symptom. In children, such gains may include being sent home from school or averting physical abuse.
A history of physical or sexual abuse should be considered when PNES are diagnosed. In children, less severe stresses such as high academic pressure or bullying at school also may cause symptoms.
A number of physical features during seizure episodes are suggestive of PNES. The eyes are usually closed.30 Asynchronous clonic limb movements (flailing) are often present. Other symptoms include pelvic thrusting and prominent rotatory (horizontal back and forth) head movements. An unusual lack of concern about the symptoms (la belle indifference affect) is typical. Also, it is unusual for persons with PNES to have the seizures during sleep. Incontinence and self injury also are less common during PNES than in epileptic seizures.31
The above-noted symptoms are suggestive but not definitive. It is important to document the nonepileptic nature of these disabling events; video EEG monitoring is most trusted. It may be challenging to get the suspicious event to occur in the clinical setting. Various forms of suggestion have been used to trigger events, but ethical considerations need to be acknowledged. Hypnosis also has been successfully used in both adults and in children to provoke PNES.32,33
It is never adequate to simply give a diagnosis of PNES without further treatment. The episodes remain disabling despite reassurance that the spells are not epilepsy. If the underlying stresses contributing to the spells go untreated, and if adequate coping mechanisms are not adopted, it is likely that the spells will continue. Referral for psychological counseling is necessary. Early diagnosis of PNES carries a better prognosis for remission.34,35
EPILEPTIC SEIZURE TYPES
Generalized motor seizures. The types of generalized motor seizures (Table 2) are relatively easy to diagnose based on patient history. However, there are physiological and psychogenic behaviors that can be mistaken for these relatively dramatic epileptic seizures. Nonepileptic events that suggest generalized motor seizures include chorea, athetosis, dystonia, and opisthotonus. Because such behaviors are frequently (but not exclusively) encountered in developmentally disabled persons, a history of normally maintained consciousness and awareness may be difficult to ascertain.
More complex movements, such as chorea or athetosis, are characterized by writhing or jerking. They are usually distinguishable from seizures because of the absence of a clear rhythmic component (unlike clonic seizures). The movements are often bilateral and awareness is maintained. Because the movements may be generalized or focal, they may be mistaken for either generalized or partial seizures.36
Absence seizures. These seizures are characterized by discrete episodes of unresponsive staring and are sometimes accompanied by minor automatisms such as eye blinking or head titubation. In the untreated person, they usually occur many times a day. Each episode may last from a few to about 30 seconds. The frequency of the seizures, their short duration, and the relative absence of automatisms help distinguish absence seizures from complex partial seizures.
Behavioral nonepileptic events such as inattention or daydreaming may be hard to distinguish from absence seizures unless there is a clear history of a lack of response to physical stimulation. An EEG is helpful, because untreated persons with absence epilepsy will almost always have generalized spike wave discharges. Atypical absence seizures are usually longer and have more accompanying subtle motor symptoms. They are commonly seen in cognitively impaired persons who have other, more obvious seizure types. Lennox-Gastaut syndrome is a common setting for atypical absence seizures.37
Partial seizures. These seizures present the greatest diagnostic challenge because of the many symptoms that can be manifestations of epileptic activity. Loss of awareness is a clinical feature that distinguishes complex from simple partial seizures. A wide variety of automatisms can be present during partial seizures depending on the part of the brain involved. Seizures arising from the frontal convexity or parasagittal region often are associated with prominent motor signs. Subtler motor activity that may be mistaken for absence seizures is indicative of orbital frontal and frontopolar seizures. Typical temporal lobe symptoms may include dizziness, staring, autonomic changes, and subtler, semipurposeful automatisms such as picking at clothes and chewing. Parietal and occipital onset is suggested by initial sensory and visual symptoms, respectively.
SUBTLE OR SUBCLINICAL SEIZURES
There are some circumstances in which seizure manifestations may be quite subtle and may show up only on an EEG. Patients in an unexplained coma or with waxing and waning levels of consciousness may be experiencing subtle seizures or nonconvulsive status epilepticus. An unexplained acute encephalopathy, particularly in the setting of a brain insult, should raise the possibility of seizure and prompt an EEG evaluation. Furthermore, patients with acute illnesses may be deeply sedated, and it has been well demonstrated that a significant proportion of such patients have seizures that are not clinically apparent.38
Other conditions in which subtle or subclinical seizures should be suspected as part of the differential diagnosis are Landau-Kleffner syndrome (LKS) and continuous spike and waves during slow sleep (CSWS).
Landau-Kleffner syndrome. LKS affects children and its hallmark is aphasia in the setting of relatively mild epilepsy. To make this diagnosis, the child must demonstrate loss of language skills and have either a history of seizures or an EEG showing epileptiform abnormalities. Some 20% of affected children have epileptiform EEG abnormalities without a history of clinical seizures. No specific EEG pattern is pathognomonic, but temporal maximum spikes often are described. Treatment is aimed at reducing the frequency of interictal spike discharges using such medications as valproate, benzodiazepines, and corticosteroids. Multiple subpial transection also has been used for treatment of medically refractory cases.39,40
Continuous spike and waves during slow sleep. CSWS, also known as electrical status epilepticus during slow-wave sleep, is a condition in which nearly continuous (more than 85%) spike-wave discharges are seen on the EEG during deep slow wave sleep. Age at onset is usually 2 to 9 years, and the phenomenon is associated with language, cognitive, and behavioral impairments. Although most affected children have a history of seizures (either generalized or partial), cases identified only through EEG findings have been described. The cause may be cryptogenic or symptomatic.41
THE ROLE OF EEG
A routine EEG performed in a patient with a presumed first seizure will show epileptiform abnormalities about 7% to 34% of the time. An EEG performed in the first 24 hours after an attack increases the EEG yield to 51%.42 Repeated EEGs, sleep deprivation before the EEG, and sleep recorded during the EEG all increase the likelihood of recording epileptiform discharges.43 Nevertheless, some patients with epilepsy will persistently have normal EEGs, and some persons with epileptiform spike discharges may have a statistically increased risk but never experience a seizure.
Ideally, a seizure event should be captured on EEG, but this is seldom practical in the outpatient laboratory. If the events are reasonably frequent, a long-term EEG that records the habitual attacks helps provide diagnostic certainty.44 Outpatient ambulatory EEG systems are increasingly useful and many now have synchronized video. In situations where recording typical seizure-like events will be helpful, but seizure medications do not need to be withdrawn, ambulatory EEG can be cost effective.
For seizures with altered consciousness, the EEG will almost always show some paroxysmal change, and most of the time an evolving apparent if the seizures are epileptic. Exceptions include some frontal lobe seizures in which the epileptogenic cortex is distant from recording scalp electrodes, such as in the mesial frontal or the orbital frontal region. Even in such cases, a paroxysmal EEG change, such as slowing, will be evident, but prominent movement artifacts may obscure the EEG. Other exceptions include auras or simple partial seizures. Not enough of the cortex may be synchronized to allow recording of the rhythmic discharges from the scalp electrodes.45
Because it is important that patients who are hospitalized for video EEG recordings have their habitual seizures, antiepileptic drugs often are tapered. For patients with mixed epileptic and nonepileptic events, drug tapering presents a problem because drug withdrawal may simply uncover the epileptic attacks that were pharmacologically controlled, although the patient may also experience nonepileptic spells. It is important to document the variety of attacks in question and make sure that the video EEG captures the habitual events and not anomalous seizures that are provoked solely by medication withdrawal.
Therapeutic Agents in This Article
*Available in a generic formulation.
•The distinction between epileptic seizures and syncope can be particularly challenging. Transient loss of consciousness-particularly if accompanied by body stiffening-can suggest seizures, but positive motor signs are common in syncope.
•Conversion disorders can manifest as psychogenic nonepileptic seizures (PNES) in adults and children. A history of significant social stresses points to the possibility of PNES.
•Behavioral nonepileptic events such as inattention or daydreaming may be hard to distinguish from absence seizures unless there is a clear history of a lack of response to physical stimulation. An electroencephalogram (EEG) is helpful, because untreated persons with absence epilepsy will almost always have generalized spike wave discharges.
•An EEG performed in the first 24 hours after a presumed seizure will show epileptiform abnormalities 51% of the time. Repeated EEGs, sleep deprivation before the EEG, and sleep recorded during the EEG all increase the likelihood of recording epileptiform discharges.
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