A 28-year-old woman is evaluated for chest pain, which is considered to be esophageal in nature. Her workup has included a normal upper endoscopy, a normal barium swallow, and a normal 24-hour pH/impedance study. She has tried a twice-daily PPI for several weeks without improvement in her symptoms.

Which of the following treatments would be recommended next?

A. Venlafaxine

B. Ranitidine

C. Baclofen

D. Metoclopromide

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