Nikita S. Wilson, PharmD


Cephalosporins: How to Minimize the Risk of Neurotoxicity

February 16, 2010

Cephalosporins are usually considered relatively safe antibiotics; however, serious neurological adverse effects can occur following administration.1-5 Manifestations of cephalosporin-induced neurotoxicity may include confusion, disorientation, twitching, somnolence, myoclonus, and seizures, particularly in patients with reduced renal function.6,7 Here we discuss the mechanism, risk factors, and management of cephalosporin-induced neurotoxicity.