September 9th 2025
New data show the LP.8.1-adapted COVID-19 vaccine generates ≥4-fold antibody increases in older and high-risk adults, with no new safety concerns.
September 5th 2025
A secondary analysis of the DANFLU-2 trial found adults ≥65 receiving a high-dose flu vaccine had a 46% lower risk of myocarditis or pericarditis compared with standard-dose vaccination.
Your daily dose of the clinical news you may have missed.
September 3rd 2025
August 28th 2025
Adults Visiting the ED Are Willing to Receive Missing CDC-Recommended Vaccines, Survey Finds
More than 90% of adults making nonurgent ED visits had missed at least 1 CDC-recommended vaccine but many were willing to catch up on all of them while there.
Head-To-Head Trial Shows Dynavax’s Z-1018 Rivals Shingrix for Efficacy and Tolerability
Z-1018, which combines a glycoprotein E (gE) antigen and proprietary adjuvant, was evaluated in adults aged 50 to 69 and the 100 µg dose will advance to part 2 of the trial.
Public Awareness of HPV and HPV Vaccine Remains Low, Especially in Midwest and South, Study Finds
New data show more than one-third of US adults are unaware of HPV or the HPV vaccine, with gaps greatest in the Midwest and South, where HPV-related cancers are most common.
Vaccine Policy Shifts, Public Trust, and Countering Misinformation
Infectious disease expert Amesh Adalja, MD, discusses new vaccine policies, misinformation, and how PCPs can build confidence during National Immunization Awareness Month.
KFF COVID-19 Vaccine Survey: Policy Shifts, Trust Gaps, and Vaccine Intentions
A recent poll reveals most US adults are hesitant about fall COVID-19 vaccinations, highlighting confusion over federal policies and declining trust in health agencies.
JN.1 COVID-19 Booster Safety Confirmed in Danish Study of More than 1 Million Older Adults
Danish adults aged 65 and older at high-risk for serious infection with SARS-CoV-2 showed no increased risk of 29 serious adverse events following vaccination.
What's the Mood Among Infectious Disease Experts Right Now? We Asked William Schaffner, MD
Schaffner describes the mood among his colleagues in infectious disease right now as anxious, perplexed, distressed, and angry. They expect the disruptions and their feelings to continue.
Reframing Vaccines as Innovation: A Strategy to Rebuild Patient Trust in Primary Care
Infectious disease physician Amesh Adalja, MD, explains how PCPs can reframe vaccines as health technology to boost confidence and counter hesitancy.
Amesh Adalja, MD, on How PCPs Can Counter Social Media Vaccine Misinformation
Amesh Adalja, MD, explains how physicians can rebut social media vaccine claims with concise, referenced facts and patient-centered communication.
Amesh Adalja, MD, on How to Defuse Vaccine Safety Concerns Without Derailing the Visit
Dr Adalja offers evidence-based strategies to address patient concerns about aluminum and thimerosal in vaccines.
Shingrix Prefilled Syringe Gets FDA Greenlight, According to GSK
The prefilled syringe presentation streamlines administration of the vaccine, eliminating the need to combine the lyophylized antigen and separate adjuvant.
FDA to Review GSK's Application for Expanded Use of RSV Vaccine in High-Risk Adults Aged 18 to 49
GSK's RSV vaccine Arexvy would join shots from Pfizer and Moderna for the younger adult population, broadening choice for those with risk factors for severe disease.
Adult Vaccines in the US: More Shots, New Dynamics on the Horizon
The adult vaccine market is poised for explosive growth, with more than 100 product launches expected over the next 10 years. Are US clinicians ready?
Nonvaccine Seasonal Flu Preventive Shows Promise in Phase 2b Clinical Trial: Cidara Therapeutics
CD388, an investigational nonvaccine antiviral, demonstrated efficacy up to 76% against influenza in a cohort of more than 5000 healthy, unvaccinated adults.
Moderna's mRNA-1010 Flu Vaccine Proves Superior Efficacy in Pivotal Late-Stage Trial
The vaccine showed superior relative vaccine efficacy that was 26.6% higher than a licensed standard-dose influenza vaccine, Moderna reported.
FDA Advisory Panel Recommends Continued Use of Monovalent JN.1 Strain for COVID-19 Vaccines
FDA panel endorses continued use of monovalent JN.1 strain for COVID-19 vaccines, aligning with global health recommendations amid evolving variants.
Moderna Announces Withdrawal of BLA for Flu/COVID-19 Combination Vaccine
Moderna voluntarily withdrew the BLA after consultation with the FDA and will resubmit once it has additional phase 3 efficacy data for its investigational flu shot.
Single Dose of Arexvy RSV Vaccine Shows 3-Year Protection in Older Adults: Daily Dose
FDA Grants Novavax COVID-19 Vaccine Full Approval for High-Risk Groups
Nuvaxovid (NVX-CoV2373) is indicated for those aged ≥65 years and aged 12 to 64 years with at least one condition that puts them at high risk for severe infection.
Pertussis: A Brief Backgrounder for Primary Care
Cases of whooping cough in the US more than doubled in 2024, and 2 infants have died from the infection. Here is background on the infection and vaccine.
False Beliefs about MMR Vaccine, Measles Reach the Majority of US Adults: KFF Poll on Health Information & Trust
Misinformation about measles and the MMR vaccine has reached the majority of US adults and parents; most believe the vaccine is safe but many are still unconvinced.
Novavax JN.1 COVID-19 Vaccine Linked to Fewer Side Effects Than mRNA in Health Care Workers
Novavax’s COVID-19 vaccine was linked to fewer and less severe side effects vs mRNA in a University of Utah study of health care workers.
The Road to RSV Vaccines in the US: A Timeline Topline
Respiratory syncytial virus was deadly and untreatable across the lifespan until 2023 when the first vaccines were approved in the US. Follow the timeline, here.
Second Measles-Related Death in a Child Reported in Texas as US Cases Surpass 600
As the US measles outbreak tops 600 cases, Texas reported a second child's death in a young girl who was unvaccinated and had no underlying health conditions.
Sanofi's Chlamydia Vaccine Granted FDA Fast Track Designation
The FDA granted fast track designation to Sanofi’s chlamydia vaccine candidate today, aiming to prevent infections and address an unmet public health need.
Improved HPV Vaccination Coverage May Help Prevent Noncervical Cancers in People with HIV
CROI 2025: Increased HPV vaccine coverage could reduce HIV cases by thousands, according to a new study.
US Adult Vaccination Snapshots: Current Coverage, Trends, and Concerns
Get the latest immunization updates, data on racial disparities, and practical guidance for clinical practice, here.
FDA Approves Pentavalent Meningococcal Vaccine Penmenvy: Daily Dose
FDA Authorizes Aptitude Metrix COVID/Flu Multiplex Molecular Test for Home and Point-of-Care Use
The Metrix COVID/Flu molecular test detects and differentiates SARS-CoV-2, influenza A, and influenza B in approximately 20 minutes.
FDA Approves GSK's Pentavalent Meningococcal Vaccine Penmenvy
The ACIP of the CDC will meet on February 26 to vote on recommendations for appropriate incorporation of Penmenvy into the routine vaccination schedule.