5-Question Quiz on HCV

February 15, 2018

It's a short quiz but it covers a broad range of knowledge about testing, treatment, and drug choices in persons with HCV infection.

Test your recall of facts about infection with hepatitic C virus, the sequence of tests to be ordered, and the characteristics of drugs used to treat persons with the disease. There are 5 questions, they won't take long, and you'll get a brush-up on basics along the way.  

1. According to the CDC, which HCV-infected persons should be treated for HCV:

A. Only those with advanced fibrosis (eg, Stages 3-4)

B. Only those with minimal-to-moderate fibrosis (eg, Stages 0-2)

C. Everyone who is HCV antibody-positive, regardless of the degree of fibrosis

D. Everyone who has a detectable HCV viral load, except for those with a “short” life expectancy

Please click “next” for answer and next question

The correct answer is D. Everyone who has a detectable HCV viral load, except for those with a “short” life expectancy should be treated for HCV.

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2. What is the initial test that is most commonly used for HCV screening?

A. HCV RNA by PCR

B. Anti-HCV (ELISA)

C. Liver biopsy

D. Liver function tests

Please click “next” for answer and next question

The correct answer is B. Anti-HCV (ELISA)

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3. Which of the following classes of FDA-approved HCV drugs has a high intrinsic barrier to the development of resistance?

A. NS5B non-nucleoside polymerase inhibitors

B. NS5A inhibitors

C. NS3/4A protease inhibitors

D. NS5B nucleoside polymerase inhibitors

Please click "next" for answer and next question


The correct answer is D.
NS5B nucleoside polymerase inhibitors

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4. What is the most common symptom associated with chronic HCV infection? A. Jaundice

B. Fever with or without jaundice

C. Abdominal pain with or without ascites

D. Asymptomatic

Please click “next” for answer and next question

The correct answer is D. Asymptomatic (most common symptom associated with chronic HCV infection

****************************5. Which one of the following drugs/components of HCV treatments needs to be adjusted if a patient is on medications that are cytochrome p450 3A/4 inducers or inhibitors?

A. Sofosbuvir

B. Velpatasvir

C. Paritaprevir

D. Daclatasvir
 

Please click "next" for answer.

The answer is D. Daclatasvir (needs to be adjusted if a patient is on medication that induces/inhibits cytochrome p450 3A/4).

 

Resources

Hepatitis C and Primary Care: Introduction

Hepatitis C Report: Tuning in to a Silent Epidemic

Hepatitis C Screening for High Risk Patients

Hepatitis C Report: What Tests to Order

Medicaid Is Tight on Hepatitis C Drug Coverage

Newer Hepatitis C Drugs Mean Direct Action

Hepatitis C Drugs Meet Resistance Issues