Aggressive Breast Tumor Subtype Predominates in Young Black Women

June 8, 2006

CHAPEL HILL, N.C ? Genetic profiling may have uncovered a strong clue about why African-American women have such a high breast cancer mortality rate.

CHAPEL HILL, N.C., June 8 ? Gene-expression profiling may have uncovered a strong clue about why young African-American women have such a high breast cancer mortality rate.

In a population-based case-control study of breast cancer, investigators at the University of North Carolina determined that a fast-growing basal-like subtype was significantly more prevalent among premenopausal African American women (39%) than among postmenopausal African American women (14%) and non-African American women (16%) of any age (P

Breast cancer-specific survival differed by subtype (P

The HER2-positive+/ER-negative subtype did not vary with race or menopausal status.