The statistics on COVID-19 signs, symptoms, progression, and spread in China put the world on notice.
The World Health Organization (WHO)-China Joint Mission on Coronavirus Disease 2019 (COVID-19) convened from February 16-24, 2020 to compile data on the signs, symptoms, progression, and severity of the coronavirus disease 2019 (COVID-19) in an effort to inform and prepare response to spread outside China.The world has shifted irreversibly since that report but the course of the infection has largely followed early trends, eg: Median time from onset to clinical recovery for mild cases is ~2 wks; 3-6 weeks for severe or critical disease. Time from onset to the development of severe disease, including hypoxia, is 1 week. Among patients who have died, the time from symptom onset to outcome ranges from 2-8 weeks.Details on mild, moderate, and severe cases and more from the final report in the slides below.
Among 55,924 laboratory confirmed cases reported as of 20 February 2020, the median age is 51y (2d-100y; IQR 39-63y) with the majority of cases (77.8%) aged 30–69y.
Symptoms of COVID-19 are non-specific and the disease presentation can range from no symptoms (asymptomatic) to severe pneumonia and death.
Additional COVID-19 typical signs and symptoms observed in China: shortness of breath, sore throat, headache, myaglias/arthralgias.
COVID-19 typical signs and symptoms seen in China: chills, nausea/vomiting, nasal congestion, diarrhea, hemoptysis, conjunctival congestion.
80% of laboratory confirmed patients have had mild-to-moderate disease, which includes non-pneumonia and pneumonia
13.8% of patients have severe disease (dyspnea, respiratory frequency ≥30/minute, O2 saturation ≤93%, PaO2/FiO2 ratio <300, and/or lung infiltrates >50% of the lung field within 24-48 hours).
6.1% of patients are critical (respiratory failure, septic shock, and/or multiple organ dysfunction/failure).
Individuals at highest risk for severe disease and death are those aged >60 yrs and those with underlying conditions such as diabetes, hypertension, CV disease, chronic respiratory disease and cancer
Disease in children is so far relatively rare & mild with ≈2.4% of total reported cases seen among those aged <19 years.
Crude fatality rates or patients with comorbid conditions including CV disease, diabetes, hypertension, chronic respiratory disease, cancer.
Median time from onset to clinical recovery for mild cases is 2 weeks. Median time for severe or critical disease from onset to recovery is 3 to 6 weeks.
Time from disease onset to development of severe disease, including hypoxia is 1 week. Time from symptom onset to outcome among patients who have died is 2 to 8 weeks.