Erosive Dermatits, Arthritis, and Urethritis: Dx?

January 18, 2017
Jonathan A. Schneider, DO
Jonathan A. Schneider, DO

This serious symptom constellation is seen in a 21-year-old man. Is it familiar to you?

A 21-year-old male with a history of chronic aphthous mouth ulcers is seen with a diffuse severe erosive dermatitis accompanied by arthritis; he also has genitourinary symptoms suggestive of urethritis and ocular signs associated with vitritis and retinal vasculitis.

Taken together the elements of this presentation point to which of the following?