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How to Handle Chronic Cough in Kids:


ABSTRACT: A cough is considered chronic when it persists for 3 or more weeks. Typically, chronic cough is a lingering manifestation of a viral upper respiratory tract infection; other, more serious causes-such as asthma, sinusitis, or gastro- esophageal reflux-must also be considered. Look to the history for diagnostic clues and order a chest film, which may point to pneumonia, hyperinflation, atelectasis, or cardiac or pulmonary abnormality. Diagnostic test methods will depend, in part, on the child's age; for example, the American Academy of Pediatrics recommends against imaging of the sinuses in children 6 years or younger. Pulmonary function tests can be useful in diagnosing asthma if the child is able to cooperate. Consider ordering a barium swallow for a very young child whose cough may be the result of a vascular anomaly. A pH probe study can help you determine whether cough is secondary to gastroesophageal reflux. Treatment is directed at the underlying cause.

The patient is a 4-year-old boy who has been coughing persistently for the past 2 months. The mother reports that about the time the coughing began, the child had a "cold" with nasal congestion and fever. These symptoms resolved, but a cough ensued. The mother tried using over-the-counter medications, including cough suppressants, but the cough has not abated. It occurs during the day and at night. It is disrupting the child's sleep, and the teachers at his day-care center are concerned that he may be infecting other children.

This scenario is all too familiar to primary care clinicians who are faced with a child with chronic cough-and his or her tired and frustrated parents. A child with a persistent cough is a source of both concern and potential disruption for the parents, other family members, and playmates and classmates. Parents want to know why their child is coughing and want the coughing to cease.

How will you approach the child with a chronic cough? How do you efficiently mine the history for key diagnostic clues? What diagnostic tests are most appropriate? The answers to these questions are the focus of this review. We present an algorithm that offers a practical approach to the diagnostic workup.


A cough that persists for at least 3 weeks (and usually 6 weeks or longer) is considered chronic.1 Every day in our pediatric clinic, we see children with cough that lingers after a viral upper respiratory tract infection (URI). The challenge is to determine whether the persistent cough is just a resolving symptom of the URI-or whether it is a manifestation of a serious condition that requires more aggressive therapy. In children without a preceding URI or obvious lower respiratory tract infection, other causes must be considered. Key diagnostic possibilities include asthma, sinusitis, and gastroesophageal reflux, which are the most commonly reported causes of persistent cough. Allergic rhinitis often goes hand in hand with asthma and sinus-itis and contributes to exacerbations of both these conditions.


Many studies detail the causes of chronic cough in childhood.2-6 Bacterial lung infections usually produce acute respiratory symptoms that readily point to the diagnosis. However, some infectious agents can invade the pulmonary system and produce insidious or prolonged symptoms: these agents include respiratory syncytial virus, cytomegalovirus, Mycoplasma,Bordetella pertussis, Ureaplasma urealyticum, Chlamydia trachomatis, and Mycobacterium tuberculosis.

The usual causes. Holinger and Sanders4 determined that the most common causes of chronic cough among patients in their otolaryngology clinic between 2 months and 15 years of age were (in descending order of occurrence):

  • Cough variant asthma.
  • Sinusitis.
  • Gastroesophageal reflux.

Gastroesophageal reflux and vascular anomalies were the most common causes of chronic cough in children 18 months and younger.4 Asthma was a close third, followed by tracheomalacia, sinusitis, and subglottic stenosis. Other diagnoses included "viral" infection, bronchogenic cyst, cystic fibrosis, and foreign-body aspiration. Sinusitis was the most common cause of chronic cough among those aged 18 months to 6 years, followed by asthma, subglottic stenosis, and gastroesophageal reflux. The most common causes of chronic cough among children 6 to 16 years old were (in descending order) asthma, psychogenic cough, sinusitis, gastroesophageal reflux, and subglottic stenosis. Interestingly, even though asthma was the most common cause of cough in this age group, it was also the most erroneous diagnosis made by the referring clinician; this finding serves as a reminder that other causes need to be considered.

Palombini and colleagues5 described the multicausal pathogenesis of chronic cough in their teenage and adult patients and stressed the frequent association of asthma, postnasal drip, and gastroesophageal reflux. These 3 conditions-alone or in combination-accounted for 93.6% of the causes of chronic cough.

Clues to uncommon causes. A study in India found that the most common causes of chronic cough in children between ages 1 and 12 years were (in descending order of frequency) asthma, tuberculosis, sinusitis, pertussis, gastroesophageal reflux, and infections other than tuberculosis.6 This study brings to light the role that some infectious agents play in causing chronic cough and underscores the importance of a detailed history of where a child lives or has traveled. Pertussis may cause persistent cough in a susceptible adult who serves as the source of infection for the child.

Tuberculosis deserves special mention because of its impact worldwide. Children who are in contact with a high-risk adult are vulnerable to tuberculosis infection. High-risk adults are those born in countries in which tuberculosis is endemic; residents of correctional facilities, shelters, or nursing homes; illicit drug users; persons infected with HIV; health care workers; and the homeless.7

Miscellaneous causes. Children who are exposed to first- or second-hand smoke, environmental air pollution, or allergens may also present with chronic cough.8 Congenital anatomic defects, cystic fibrosis, and immotile cilia syndrome can cause chronic cough; typically, other symptoms of these disorders are evident-such as failure to thrive, GI abnormalities, and recurrent infection.

The importance of the history and physical. The clinical history offers clues to the cause of chronic cough. For example, exacerbation of cough with exercise or meals suggests asthma or gastroesophageal reflux disease, while unrelenting URI symptoms suggest sinusitis. Past personal and family history of allergies, asthma, recurrent infections, failure to thrive, and smoke exposure needs to be detailed. A history of travel to foreign countries or contact with an adult with a chronic cough offers clues to the possibility of tuberculosis or pertussis.

A thorough examination-especially of the respiratory and GI tracts and the cardiovascular system-is indicated, and signs of pulmonary disease (eg, tachypnea, wheezing, or clubbing of the nails) should be sought. Positive factors in the history and physical examination suggest the appropriate diagnostic path.


The Algorithm outlines our approach to the child with a chronic cough. The sequence of testing is flexible and depends on the availability and practicality of obtaining specific tests for specific patients.

Chest films. We recommend obtaining a chest roentgenogram in all children with chronic cough. The goal is to detect any suggestion of a pulmonary, cardiac, or thoracic abnormality that may prompt further investigation-such as bronchoscopy or CT or MRI of the chest. Often, the chest film is normal, but it may reveal a possible pneumonia, hyperinflation, atelectasis (as in a patient suffering from asthma or foreign-body aspiration), or other cardiac and pulmonary abnormalities (Figure). Keep in mind that not all foreign bodies are visualized on plain chest films.

Sinus x-ray films and CT scans. Infected sinuses should be considered in all children with chronic cough. Whether to order a sinus x-ray film or a sinus CT scan to confirm this diagnosis is controversial, however. The American Academy of Pediatrics (AAP) recommends against imaging of the sinuses in children aged 6 years or younger as an aid in the diagnosis of acute bacterial sinusitis. The AAP recommends CT scanning for patients who are possible candidates for surgery.9

High-quality sinus x-ray films can be nearly impossible to obtain in a young child, and interpretation can be quite challenging and subjective. We have not found sinus x-ray films to be helpful in the very young child with chronic cough, although these films have occasionally helped us diagnose sinus disease in older children.

Although studies refer to CT as the "gold standard,"10 it is not always practical to obtain such a scan immediately, and a child may need to be sedated for the procedure. Nevertheless, a CT scan can provide valuable information and should be considered for a child who is coughing persistently. At the lead author's institution, a sinus x-ray film can be obtained and reviewed within a few hours; a sinus CT scan, however, must be scheduled for a later time-especially if sedation is required for the procedure.


Pulmonary function tests. In children who are able to cooperate, spirometry aids in the diagnosis of asthma. It is possible to obtain consistent pulmonary function test results in children aged 5 years or younger, but this is not always feasible.11 In these young children, the diagnosis of asthma is based on a history of recurrent cough and wheezing that responds to bronchodilators, such as albuterol.

Barium swallow. This testcan provide additional information about the child's anatomy; abnormal results may prompt further evaluation with CT or MRI of the chest.

Consider ordering a barium swallow especially for the child who has a chronic cough during the first few years of life. This test may suggest the presence of a vascular anomaly (such as an aberrant innominate artery), a major cause of chronic cough among young children.3

pH Probe. If the chest film, sinus film, sinus CT scan, and/or barium swallow fail to elucidate the cause of chronic cough, a pH probe study is recommended to determine whether gastroesophageal reflux is the underlying problem. Referral to a pediatric gastroenterologist for this procedure may be warranted.

Miscellaneous tests. Consider testing for tuberculosis with a purified protein derivative test, performing a sweat chloride test, and ordering an evaluation for immunodeficiency disorders. Because laboratory confirmation of many uncommon infectious agents can be difficult, an infectious disease specialist should be consulted.

The anatomy must be examined via endoscopy from the nares to the lungs and the mouth to the stomach. Endoscopy is particularly helpful in the young infant,4 but can be helpful in persons of all ages.

An allergist/immunologist can aid in the evaluation for underlying allergies or immunodeficiency.


Here we offer treatment suggestions for the most common causes of chronic cough. A discussion of treatment of various infections is beyond the scope of this article; the Red Book serves as an excellent source for up-to-date recommendations.12 The consensus panel report by Irwin and colleagues13 summarizes the American College of Chest Physicians' recommendations for managing cough; most of these recommendations can be applied to pediatric patients as well.

At any point during the workup for chronic cough (see Algorithm), you may want to consider empiric therapy for asthma or sinusitis-especially when optimal testing may not be available because of the patient's age. The safety and cost-effectiveness of this approach have not been established for pediatric patients (as they have for adults14,15), but a trial may be desirable in some children (for example, in an infant with a persistent cough following an uncomplicated URI).

Asthma. This disease must be treated aggressively so that the child is symptom-free. Anti-inflammatory medications, such as inhaled corticosteroids-at the lowest effective dosages-are recommended for the treatment of all "persistent" grades of asthma, with the possible addition of leukotriene modifiers. Inhaled long-acting β2-agonists are also recommended when a child experiences severe persistent asthma (ie, symptoms that occur daily and frequently at night).16 Inhaled short-acting β2-agonists are also used for symptom relief. The clinician's time is well-spent in educating the family about asthma and its treatment-and in reinforcing that education.

Sinusitis. The AAP recommends antibiotic therapy for pediatric patients with acute bacterial sinusitis but acknowledges that the optimal duration of therapy has not been determined. Chronic inflammation of the sinuses accompanied by symptoms that persist for at least 90 days may be caused by disorders such as gastroesophageal reflux, underlying allergies, pollution exposure, and cystic fibrosis.9 As with chronic cough, the precise cause of the chronic sinus disease needs to be determined and treated. Certainly, many children suffer from asthma, allergies, and sinusitis simultaneously-and all need to be aggressively controlled.

Gastroesophageal reflux. The many available treatment modalities-such as upright positioning, thick- ened feeding formula for very young children, H2 blockers, proton pump inhibitors, motility agents, and sur- gery-have been studied to varying degrees in children. The severity of the child's symptoms dictates the extent of therapy.

Psychogenic cough. This phenomenon can sometimes be alleviated by wrapping a bedsheet tightly around the patient's chest and convincing him that the bedsheet will aid the chest muscles in eliminating the cough.17 Bye18 reported that a peak flow meter provided positive feedback to an asthmatic child suffering from a psychogenic cough and helped eliminate that cough. Perhaps offering a non-asthmatic child concrete evidence of a normal peak flow may bring relief from psychogenic cough.In some cases, a behavioral medicine consultation may be required to stifle the psychogenic cough.


Congenital anomalies and other less common causes of chronic cough often require the expertise of a pediatric specialist (such as a pulmonologist, cardiologist, or surgeon) for definitive treatment. Whether they are needed to correct an anatomic abnormality, remove a foreign body, or offer further treatment options, the pediatric specialist needs to be involved. Patients with certain illnesses, such as cystic fibrosis, require a multidisciplinary approach.


REFERENCES:1. Black P. Evaluation of chronic or recurrent cough. In: Hilman CH, ed. Pediatric Respiratory Disease: Diagnosis and Treatment. Philadelphia: WB Saunders Company; 1993:143.
2. Holinger LD. Chronic cough in infants and children. Laryngoscope. 1986;96:316-322.
3. Bremont F, Micheau P, LeRoux P, et al. Etiology of chronic cough in children: analysis of 100 cases. Arch Pediatr. 2001;8(suppl 3):645-649.
4. Holinger LD, Sanders AD. Chronic cough in infants and children: an update. Laryngoscope. 1991; 101(6, pt 1):596-605.
5. Palombini BC, Villanova CA, Araujo E, et al. A pathogenic triad in chronic cough. Chest. 1999;116: 279-284.
6. Mogre VS, Mogre SS, Saoji R. Evaluation of chronic cough in children: clinical and diagnostic spectrum and outcome of specific therapy. Indian Pediatr. 2002; 39:63-69.
7. Ampofo KK, Saiman L. Pediatric tuberculosis. Pediatr Ann. 2002;31:98-108.
8. Cook DG, Strachan DP. Health effects of passive smoking. 3. Parental smoking and prevalence of respiratory symptoms and asthma in school age children. Thorax. 1997;52:1081-1094.
9. American Academy of Pediatrics. Subcommittee on Management of Sinusitis and Committee on Quality Improvement. Clinical practice guideline: management of sinusitis. Pediatrics. 2001;108:798-808.
10. Konen E, Faibel M, Kleinbaum Y, et al. The value of the occipitomental (Waters') view in diagnosis of sinusitis: a comparative study with computed tomography. Clin Radiol. 2000;55:856-860.
11. Crenesse D, Berlioz M, Bourrier T, et al. Spirometry in children aged 3 to 5 years: reliability of forced expiratory maneuvers. Pediatr Pulmonol. 2001;32:56-61.
12. American Academy of Pediatrics. In: Pickering LK, ed. Red Book: 2003 Report of the Committee on Infectious Diseases. 26th ed. Elk Grove Village, Ill: American Academy of Pediatrics; 2003.
13. Irwin RS, Boulet LP, Cloutier R, et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest. 1998;114:133S-181S.
14. Lin L, Poh KL, Lim TK. Empirical treatment of chronic cough-a cost-effectiveness analysis. Proc AMIA Symp. 2001:383-387.
15. Ours TM, Kavuru MS, Schilz RJ, Richter JE. A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough. Am J Gastroenterol. 1999;94:3131-3138.
16.National Asthma Education and Prevention Program Expert Panel Report Guidelines for the Diag- nosis and Management of Asthma-Update on Selected Topics 2002. Bethesda, Md: National Institutes of Health; 2002. NIH publication 02-5075.
17. Cohlan SQ, Stone SM. The cough and the bedsheet. Pediatrics. 1984;74:11-15.
18. Bye MR. Use of a peak flow meter for positive feedback in psychogenic cough. Pediatrics. 2000;106: 852-853.
19. Bell EA. Pharmacologic treatment of cough: which product to use in children? Infect Dis Children. 2001;June:6-9.
20. American Academy of Pediatrics Committee on Drugs. Use of codeine- and dextromethorphan-containing cough remedies in children. Pediatrics. 1997;99:918-920.

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