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Leukocytoclastic Vasculitis Caused by Systemic Lupus Erythematosus
These hyperkeratotic, hemorrhagic, depressed ulcerations developed on the feet of a 45-year-old white man with a 4-year history of systemic lupus erythematosus (SLE).
These hyperkeratotic, hemorrhagic, depressed ulcerations developed on the feet of a 45-year-old white man with a 4-year history of systemic lupus erythematosus (SLE).
Biopsy of a single lesion showed the typical changes of leukocytoclastic vasculitis caused by SLE. In addition, the patient had many other criteria for SLE, including malar and discoid rashes, photosensitivity, oral ulcers, arthritis of the hands, impaired mentation, anemia, persistent proteinuria, and positive antinuclear antibody and anti-DNA.
The vasculitis appeared after the patient's oral prednisone was decreased from 40 to 20 mg/d. When the medication was increased to 35 mg/d, new lesions stopped forming and the existing ones gradually healed.
(Case and photograph courtesy of Reynold C. Wong, MD.)
Primary Viewpoints Episode 7: Antidepressants for Back Pain, Osteoarthritis Pain
February 25th 2021Listen to our newest podcast episode where the lead author of a recent meta-analysis shares his findings on the safety and efficacy of antidepressant medications to treat back and osteoarthritis pain.
Podcast: Arthritis, Anxiety, and Depression: Managing a Common Comorbidity
May 14th 2012Anxiety is even more common than depression among people who have arthritis, a new study has shown. Here to discuss the implications for diagnosis and treatment is Eilzabeth Lin MD, a family medicine physician who is a longstanding researcher in the field of depression and pain.
