OSTEOPOROSIS: PATHOPHYSIOLOGY AND CLINICAL MANAGEMENT

December 31, 2006

One of every 4 women older than 45 years-and 9 of every 10 women older than75-has osteoporosis. Here the editors take a novel approach to this “silent epidemic.”Chapters dealing with basic science questions and findings are juxtaposed withchapters covering similar issues from a clinical standpoint. Traditional issues, suchas calcium supplementation and exercise, are coupled with state-of-the-art updateson molecular pharmacology and ultrasound imaging. On the basic science side,topics include the genetics of osteoporosis, molecular bone turnover markers, androgensand skeletal homeostasis, biology of estrogen and bone, and cellular and molecularaspects of immunosuppressant osteoporosis. On the clinical side, expertspresent the latest thinking on bone densitometry, therapy with vitamin D and itsmetabolites, salmon calcitonin, parathyroid therapy, bisphosphonates, and selectiveestrogen receptor modifiers. CT and ultrasound scans, photomicrographs, tables,and charts accompany the well-referenced text.

One of every 4 women older than 45 years-and 9 of every 10 women older than75-has osteoporosis. Here the editors take a novel approach to this "silent epidemic."Chapters dealing with basic science questions and findings are juxtaposed withchapters covering similar issues from a clinical standpoint. Traditional issues, suchas calcium supplementation and exercise, are coupled with state-of-the-art updateson molecular pharmacology and ultrasound imaging. On the basic science side,topics include the genetics of osteoporosis, molecular bone turnover markers, androgensand skeletal homeostasis, biology of estrogen and bone, and cellular and molecularaspects of immunosuppressant osteoporosis. On the clinical side, expertspresent the latest thinking on bone densitometry, therapy with vitamin D and itsmetabolites, salmon calcitonin, parathyroid therapy, bisphosphonates, and selectiveestrogen receptor modifiers. CT and ultrasound scans, photomicrographs, tables,and charts accompany the well-referenced text.