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Prediabetes Subphenotyping: A Novel Approach to Type 2 Diabetes Prevention


New research proposes pathophysiology-based subphenotyping of individuals at increased risk for T2D; 6 are suggested to help refine screening, prevention, and treatment.

Prediabetes is widely recognized as predisposing patients to a higher probability of progression to type 2 diabetes (T2D) and the elevated glycemic condition itself increases risk of micro- and macrovascular complications.

But not all patients with prediabetes are alike.

German researchers recently proposed subphenotyping of patients at increased risk for T2D in an effort to improve screening, prevention, and treatment strategies. Their findings were reported recently on the preprint server MedRxiv, in the journal Nature Medicine, and a review article in Diabetes Therapy.

For a concise summary of the research and characteristics of the 6 prediabetes subphenotypes identified, click through the slides below.

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