Probiotic Therapy: Level I Evidence for Which Condition?

Probiotic therapy has level 1 evidence for only one condition-acute infectious diarrhea.

Probiotics have been used to manage all of the conditions below. Which of the following is the only condition with Level I evidence (well-conducted, controlled studies)?

A. Acute infectious diarrhea
B. Irritable bowel syndrome
C. Hepatic encephalopathy
D. Clostridium difficile infection

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