
Takeda’s oral TYK2 inhibitor showed rapid skin clearance in phase 3 psoriasis trials as FDA fast-tracks review; decision expected early 2027.
PT Video: A short course of steroids was ineffective. He returns to ED c/o worsening joint and abdominal pain. Can you Dx?
A 16 y/o male presents with 9 days palpable, purpuric, non-pruritic rash that began on legs and spread quickly upwards; also c/o polyarticular arthritis, abdominal pain. Mild improvement after short course of steroids, finished 2 days ago. Joint/abdominal pain now worse. PMH, noncontributory; no sick contacts. What else do you need to know?
What is your initial impression?