What Cause of Bloating, Oily Stool, and Diarrhea?

January 7, 2019

These symptoms are recurrent despite patient's adherence to enzyme replacement therapy for pancreatitis. Your next step?

A 54-year-old woman with a history of chronic pancreatitis secondary to alcohol abuse presents to your office with a chief complaint of diarrhea, weight loss, and foul-smelling, oily stools. After an appropriate workup, you diagnose her with exocrine pancreatic insufficiency and initiate pancreatic enzyme replacement therapy. She responds well to the medication and her diarrhea resolves and she begins to regain the weight she lost.

She returns 6 months later  with a complaint of return of oily stools and diarrhea, this time associated with significant bloating. She says she has strictly adhered to the enzyme replacement regimen.

What is the next step in evaluation?