Mark Bloom

Articles by Mark Bloom

ROCKVILLE, Md. -- The FDA today allowed a human thrombin (Evithrom) on the market after the risk of transfusion-transmitted viral infection kept it on the sidelines for more than a half-century.

ROCKPORT, Me. -- Chief Justice John Roberts had a benign idiopathic seizure today at his summer home near here and was hospitalized as a precaution, according to the Supreme Court.

NEWCASTLE UPON TYNE, England, June 5 -- An interim analysis of the 4,447-patient RECORD trial did not confirman increased risk of myocardial infarction or cardiac death in patients taking rosiglitazone (Avandia) for treatment of type 2 diabetes, although the data suggest an increased risk of heart failure. So reported the New England Journal of Medicine online today, one day before a Congressional hearing on the safety of rosiglitazone.

CLEVELAND -- A meta-analysis of 42 randomized trials released online by the New England Journal of Medicine today found a 43% increase in the risk of myocardial infarction among type 2 diabetics treated with rosiglitazone (Avandia), although the absolute number of events was small. A journal editorial says FDA action is warranted, and a congressional inquiry is expected.

LYNCHBURG, Va. -- Televalgelism pioneer Jerry Falwell, the founder of Moral Majority and a stalwart of the Christian right wing of the GOP, died today after collapsing in his office here. Falwell was 73 and had suffered in recent years from congestive heart failure and pneumonia.

CHAPEL HILL, N.C. -- John Edwards, the former senator, announced today that his wife, Elizabeth Edwards, 57, has had a recurrence of breast cancer, a bony metastasis, but he is continuing his campaign to be the Democratic candidate for the presidency. Elizabeth Edwards had a lumpectomy in 2004 and adjuvant chemoradiation. He and his wife called the malignancy treatable. "The campaign goes on," he said.

SEATTLE -- Starbucks, the giant coffee shop chain, has announced that it is banning trans fats, climbing aboard the nutritional bandwagon championed by the city of New York and promoted by the American Heart Association.

SAN ANTONIO -- The annual incidence of breast cancer has fallen drastically, coinciding with the end of the hormone replacement therapy era, according to SEER data from the National Cancer Institute. After a steady rise during the past 20 years, the incidence dropped 7% from 2002 to 2003, reported investigators at the San Antonio Breast Cancer Symposium. The absolute reduction could be as many as 14,000 breast cancer cases per year.

SAN ANTONIO -- The annual incidence of breast cancer has fallen drastically, coinciding with the end of the hormone replacement therapy era, according to SEER data from the National Cancer Institute. After a steady rise during the past 20 years, the incidence dropped 7% from 2002 to 2003, reported investigators at the San Antonio Breast Cancer Symposium. The absolute reduction could be as many as 14,000 breast cancer cases per year.

GAITHERSBURG, Md. -- The FDA's drug-eluting stent safety panel recommended today that the labels of Cypher (sirolimus-eluting) and Taxus (paclitaxel-eluting) stents be changed to include a warning that off-label use of the devices may carry an increased risk of stent thrombosis, myocardial infarction, and death. The panel also called for the label to carry a recommendation for 12-months of dual antiplatelet therapy with aspirin and Plavix (clopidogrel) when drug-eluting stents are used off-label.

ROCKVILLE, Md. -- The FDA approved Januvia (sitagliptin) today, the first dipetidyl peptidase-4 (DDP-4) inhibitor, an oral agent for type 2 diabetes as monotherapy or in combination with Glucophage (metformin) or a PPAR agonist.

HAVANA -- President Fidel Castro, 79, one of the last of the Communist dictators, underwent intestinal surgery tonight, according to Havana television in a statement signed by the Cuban leader himself. There were no other immediate medical details. Castro's brother, Raul, was put in interim charge. Fidel Castro, whose 80th birthday is Aug. 13, took over in 1959.

ROCKVILLE, Md. -- The FDA issued a warning today to doctors and consumers to avoid the use of an ostensible therapy for Lyme disease called bismacine, also known as chromacine, that may have caused one death and multiple injuries.

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