A 70-year-old man who had just completeda course of trimethoprim-sulfamethoxazolefor a urinary tract infectionpresented with palpable purpuraand cutaneous erosions of acute onseton his legs (A). He also had massivescrotal edema and purpura (B).
A 70-year-old man who had just completeda course of trimethoprim-sulfamethoxazolefor a urinary tract infectionpresented with palpable purpuraand cutaneous erosions of acute onseton his legs (A). He also had massivescrotal edema and purpura (B).Palpable purpura is the typicalmanifestation of small-vessel leukocytoclasticvasculitis. Dusky urticarialplaques, blisters, pustules, erosions,and ulcers may be present. Dependentareas such as the acral extremitiesare most commonly affected;the lower trunk and groin may be involvedwhen patients are sedentaryor bedridden.Leukocytoclastic vasculitis maybe idiopathic or secondary to a widerange of conditions, including collagenvascular disease, cryoglobulinemia, malignancy, infections,and drugs. The agents most commonly associatedwith this condition are antibiotics (including sulfonamides,tetracycline, and penicillin); allopurinol; thiazide diuretics;and phenytoin. In this patient's case, trimethoprim-sulfamethoxazoleproved to be the culprit. Laboratory investigationmay be necessary to identify the underlying triggerand to determine whether there is concomitant systemicvasculitis.
Lebrikizumab Demonstrates Efficacy, Safety in Patients With Skin of Color With AD
June 11th 2025RAD 2025. Lebrikizumab improved skin clearance, itch, and pigmentation in patients with skin of color and atopic dermatitis, with strong safety data through 24 weeks, according to late-breaking data.