Christopher K. Finch, PharmD



Penicillin- and Carbapenem-Induced Neurotoxicity: How to Reduce the Risk

February 02, 2009

Penicillin-induced neurotoxicity was first recognized by Johnson and Walker in 1945 after intraventricular administration of benzylpenicillin.1,2 Subsequently, the β-lactams have been shown to have a higher rate of CNS effects than other classes of antibiotics.3,4

Carbamazepine-Drug Interactions: Appropriate Management Minimizes Risk

January 01, 2007

Carbamazepine is associatedwith numerousclinically significantdrug interactions.1 Thiswidely used agent ismost commonly prescribed for eitherseizure disorders or adjunctivepain management.

Serum Digoxin Concentrations: Do You Know the Current Upper Limit in Heart Failure?

December 31, 2006

For more than 30 years, serumdigoxin concentrations (SDCs)have been monitored toensure safe, effective therapy.1,2Although the therapeuticrange for SDCs is often listed as either0.8 to 2.0 ng/mL or 0.5 to 2.0ng/mL, the results of clinical trials inthe 1990s suggest an upper limit of1.0 ng/mL for treatment of heart failure.3-11 An upper limit for the SDC of1.0 ng/mL is also recommendedfor patients who have heart failureand atrial fibrillation with rapid ventricularresponse.

Update on Rifampin and Rifabutin Drug Interactions

December 31, 2006

Rifampin is associated with numerousclinically significantdrug interactions.1-4 New interactionswith rifampin-aswell as rifabutin-continue tobe reported in studies and clinical observations.Here we present highlightsof our recent update on the interactionsthat are most relevant toprimary care practice.5

Phenytoin Drug Interactions: Effects of Phenytoin on Other Drugs

May 01, 2006

A focus on the known clinically significant drug-drug interactions of phenytoin.

Pitfalls In Prescribing: Phenytoin Drug Interactions: Effects of Other Drugs on Phenytoin

March 01, 2006

Phenytoin is one of the most commonly prescribed antiepileptic drugs in both acute and chronic settings; its use has been extensively described. Nevertheless, interactions between phenytoin and numerous other drugs continue to complicate seizure therapy; these have been documented in case reports, studies, textbooks, and epilepsy reviews.

Drug Interactions With Azole Antifungals: Focus on Fluconazole and Itraconazole

May 02, 2004

Azole antifungals are widelyused to treat numerousinfections.1 Manywell-documented, clinicallysignificant drug interactionsare associated with these agents1,2