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BOSTON -- Suicidal tendencies that arise in some men who start on the antidepressant citalopram (Celexa) may be linked to genetic mutations, investigators in Boston and Dallas reported.

CHICAGO -- Neoadjuvant chemotherapy did not improve survival of patients with resectable non-small cell lung cancer (NSCLC) compared with surgery alone, researchers reported here.

OTTAWA, Ontario -- Men ought to swear off cigarettes long before they even think of having children, according to researchers here.

CHICAGO -- Localized prostate cancer needs a balanced view of treatment options from both urologists and radiologists, researchers said here.

CHICAGO -- For node-positive breast cancer, an abbreviated course of adjuvant radiation with fewer fractions and a lower total dose does not appear to add to the risk of local recurrence, British researchers said here.

CHICAGO -- Two novel therapies targeting vascular endothelial growth factor demonstrated activity in refractory thyroid and ovarian cancer, investigators reported here.

CHICAGO -- Less than a third of the survivors of childhood cancer get routine cancer-related health care as young adults, even though they are likely to have more serious need than others their age, researchers found.

CHICAGO -- Adding shark cartilage extract to chemoradiation failed to improve survival in non-small cell lung cancer (NSCLC) patients, results of a government-mandated clinical study show.

CHICAGO -- Flaxseed supplementation significantly reduced cancer cell proliferation rates in men with prostate cancer, investigators in a multicenter study found.

CHICAGO -- Adding the monoclonal antibody cetuximab (Erbitux) to standard platinum-based chemotherapy for first-line treatment of head and neck cancers prolongs overall survival, researchers said here.

CHICAGO -- Almost all patients treated off-label with dasatinib (Sprycel) for chronic myelogenous leukemia (CML) had a complete cytogenetic response within a year of beginning therapy, researchers reported here.

CHICAGO -- American ginseng, a species of plant often promoted as nature's soothing balm, may decrease fatigue associated with cancer therapy, researchers reported here.

CHICAGO, June 2 -- Adding bevacizumab (Avastin) to chemotherapy improved progression-free-survival for non-small-cell lung cancer by 33%, an absolute increase of about 21 days, found a European trial.

CHICAGO -- Second-line agents for hormone-refractory prostate cancer are emerging to fill an unmet need, researchers said here.

Drug-resistant HIV strains that pass from mother to infant can go undetected in the baby’s immune system cells and remain there for years, according to a study by Deborah Persaud, MD, of Johns Hopkins University School of Medicine and colleagues (Reuters. April 30, 2007).

Scientific discoveries typically begin with basic laboratory research followed by transition to clinical care of the patient.

Much has been written over the years about the prevalence of HIV drug resistance mutations and about the fitness and transmissibility of resistant strains of virus and their present and potential impact on the HIV pandemic.

We report the case of an HIV-positive patient with preexisting bone disease who developed tenofovir-induced Fanconi syndrome and subsequently sustained pathologic fractures. We suggest that tenofovir treatment may have contributed to the patient’s pathologic fractures through its effects on phosphorus balance and vitamin D metabolism.