Charles E. Crutchfield III, MD




Alezzandrini Syndrome

March 01, 2007

Loss of pigmentation was noted around the left eyeof a 49-year-old man-the same eye in which hehad a detached retina. In addition, the patient'shearing was impaired on that side. These findingswere consistent with the diagnosis of Alezzandrinisyndrome, the major manifestations of which includeunilateral degenerative retinitis, ipsilateral facial vitiligo,poliosis of the eyebrows and eyelashes, and ipsilateralhearing deficits.

Cutaneous Lymphoid Hyperplasia

September 14, 2005

A 51-year-old man presented with red, mildly pruritic papulonodules that had erupted on his face approximately 5 weeks earlier. The clinical appearance suggested cutaneous lymphoid hyperplasia.

Diabetic Vasculopathy

September 14, 2005

Cutaneous manifestations develop in approximately 30% of persons with diabetes. Premature atherosclerosis is a common complication of the disease that can cause peripheral infarction, ulceration, and necrosis.

Erythema Elevatum Diutinum

September 14, 2005

This rare condition affects both men and women. The average age at onset is 53 years. The lesions are deep brownish red to purple papules, nodules, and plaques. Blisters and ulcers also can occur.

Relapsing Polychondritis

September 14, 2005

Relapsing polychondritis, as manifested in one of this 55-year-old man's deformed ears, is a rare, chronic, autoimmune inflammatory disease of cartilaginous structures. The disease also affected the cartilage in this patient's nose, which is the second most common site of involvement. Tissues of the joints, eyes, and blood vessels as well as the trachea and the bronchial tree may also be affected and destroyed.

Sickle Cell Ulcer

September 14, 2005

A 39-year-old man who has sickle cell disease suffers with chronic ankle ulcers typical of the disorder. Ulcerations occur in approximately 50% of persons who are homozygous for sickle cell disease.

Favre-Racouchot Syndrome

September 14, 2005

A 67-year-old woman sought medical treatment for the persistent, large “blackheads” on her face. Examination revealed diffusely thickened and yellowed skin with deep furrows. The periorbital and malar areas were studded with large open comedones.


September 14, 2005

A 61-year-old woman who was receiving dialysis for diabetes-associated end-stage renal disease was hospitalized for care of an abdominal wound that had been debrided and closed. At this time, the patient had several large, indurated, red plaques with central, stellate, black eschars on her abdomen, left buttock, and legs. An early focus of ulceration was noted superior to the stapled incision.