Asthma

Abstract: Patients who have aspirin-exacerbated respiratory disease (AERD) usually experience upper and lower respiratory tract symptoms about 1Z|x to 2 hours after taking aspirin or another NSAID that inhibits the enzyme cyclooxygenase-1. In addition to symptoms such as nasal congestion, rhinorrhea, paroxysmal sneezing, periorbital edema, laryngospasm, and intense flushing, patients may have severe--often life-threatening--exacerbations of asthma. AERD occurs in about 10% to 20% of patients with asthma and in about 30% of asthmatic patients with nasal polyposis. However, AERD also occurs in patients who do not have any of these predispos- ing conditions. In patients with AERD, aspirin desensitization can improve asthma control, reduce the need for corticosteroids, and reduce the need for sinus surgery. (J Respir Dis. 2006;27(7):282-290)

The American Academy of Allergy, Asthma, and Immunology (AAAAI) recently published guidelines for referring patients to an allergist/immunologist.1 The recommendations address topics such as rhinitis, asthma, cough, anaphylaxis, dermatitis, urticaria, and food allergy.

A review of the environmental determinants of allergic rhinitis and asthma, including house dust mites, cats, dogs, and cockroaches.

Although the relationship is not completely understood, it is clear that anxiety and depression can adversely affect the course of asthma and chronic obstructive pulmonary disease.

Avoidance of allergens and irritants known to cause or aggravate allergic rhinitis and asthma is a key component in the management of these disorders.

WASHINGTON - Calling secondhand tobacco smoke a significant risk to cardiovascular health, the U.S. Surgeon General today praised states and municipalities that have a banned smoking in the workplace, in bars, and in other public places.

SALT LAKE CITY - Adherence to treatment with continuous positive airway pressure (CPAP) by patients with obstructive sleep apnea may be considerably less than believed.

ODENSE, Denmark ? When individual physicians take part in a drug trial, their developing familiarity with a drug they are testing makes them more likely to use it in everyday practice, suggesting that post-marketing clinical trials are an effective sales tool.

CINCINNATI - When it comes to inducing allergies in young children, not all types of airborne fungal spores are created equal, researchers here said.

LONDON, June 15 - Patients with cystic fibrosis can safely stop using inhaled corticosteroids, according to researchers here.

abstract: Pulmonary arterial hypertension (PAH) is 1 of 5 types of pulmonary hypertension (PH). Symptoms may include dyspnea on exertion, fatigue, near-syncope, and palpitations. Physical findings include lower extremity edema, jugular venous distention, and a loud P2. Findings on chest radiography, transthoracic echocardiography, and electrocardiography can suggest the presence of PAH; however, right heart catheterization is the gold standard for confirming the diagnosis and for differentiating PAH from other forms of PH. It is essential to exclude chronic thromboembolic PH, since this can be surgically corrected. The treatment of PAH depends on the severity. In addition to the standard treatments, such as diuretics and anticoagulation, more advanced treatment options include prostaglandin therapy (epoprostenol, treprostinil, and iloprost), endothelin receptor antagonists (bosentan), and phosphodiesterase inhibitors (sildenafil).

What strategies can reduce the risk of osteoporosis in patients receiving long-term glucocorticoid therapy?

Abstract: A number of factors can complicate the diagnosis of asthma in elderly patients. For example, the elderly are more likely to have diseases such as chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) that--like asthma--can cause cough, dyspnea, and wheezing. Spirometry can help distinguish asthma from COPD, and chest radiography and measurement of brain natriuretic peptide levels can help identify CHF. Important considerations in the management of asthma include drug side effects, drug interactions, and difficulty in using metered-dose inhalers. When discussing the goals of therapy with the patient, remember that quality-of-life issues, such as the ability to live independently and to participate in leisure activities, can be stronger motivators than objective measures of pulmonary function. (J Respir Dis. 2006;27(6):238-247)

CHAPEL HILL, N.C. - Inhaled corticosteroids reduce exacerbations with acceptable side effects in patients with moderate or severe COPD, but not mild disease, shows a meta-analysis.

ROCKVILLE, Md. - The FDA approved a shingles vaccine, and Merck said it is ready to accept physician orders, with rapid shipment promised.

Recent reports have identified potentialrisks of nebulizer use in patientswith environmental allergies.1,2 One report described 2 childrenwith asthma and cockroachallergy who had life-threateningworsening of asthma after using anebulizer to treat an exacerbation.1

Test your knowledge of dermatology with 4 cases, 4 photos, 4 different rashes . . . which are the result of a drug reaction?

Initiation of early aggressive therapy is critical to averting fatal outcomes in exacerbations of acute life-threatening asthma.

The morbidity and mortality of asthma can be reduced by identifying high-risk patients, using objective and subjective measures to detect severe exacerbations, and initiating early medical intervention.

Q:What constitutes the optimal management of asthma ina pregnant patient?

For 2 months, a 35-year-old woman has been troubled by a bilateral pruritic eruption on her neck. The condition did not respond to a 3-week course of oral terbinafine. The patient has a history of childhood asthma; her only current medication is an oral contraceptive. She has had a cat for the past 2 years. She has not used any new shampoos or conditioners.

A 52-year-old woman was admitted tothe hospital with progressive shortnessof breath of 2 days’ duration. Bronchialasthma had been diagnosed 6 monthsearlier; inhaled corticosteroids, bronchodilators,and leukotriene antagonistswere prescribed. Despite aggressivetreatment, the patient’s dyspneaand wheezing worsened.

Although inhaled corticosteroids play a major role in the management of asthma, their effects on bone mineral density (BMD) are a concern for some patients. Fuhlbrigge and associates evaluated the cost-effectiveness of such therapy in light of the potential adverse effects on BMD. They found that inhaled corticosteroid therapy compares favorably with other standard medical interventions. However, the use of high doses over an extended period can affect overall costs and health.

A 28-year-old man presented with chest pain, hemoptysis, and wheezing. He had a history of intermittent shortness of breath that occurred at least 3 times a year in the past 3 years; fever; and loss of appetite associated with headache, vomiting, and weakness. His medical history also included asthma, chronic gastritis, and more than 5 episodes of pneumonia since 1996. A test for hepatitis C virus (HCV) had yielded positive results.

The association between asthma and pneumococcal disease has been suspected by many clinicians; however, formal investigations confirming an increased risk of pneumococcal disease in patients with asthma are rare. Often, studies examining risk factors for pneumococcal disease have grouped all chronic pulmonary diseases together with no delineation of the specific type of underlying disease.