September 18th 2023
Results from a new study show that older adults with untreated hypertension had a 42% increased risk of dementia vs healthy controls.
July 28th 2023
The Alzheimer's Association chief science officer discusses release of updated diagnostic guidelines for AD, which incorporate use of plasma-based biomarkers.
July 27th 2023
A daily dose of clinical news on Patient Care you may have missed.
July 24th 2023
The highest risk of mortality among a Danish population with dementia occurred within 2 weeks of an opioid prescription but remained significant at 180 days.
July 17th 2023
Howard Fillit, MD, cofounder/chief scientific officer of the Alzheimer Drug Discovery Foundation, says lecenumab's approval opens the door for future drug development.
Cognitive Screening in Older Adults: How they Perceive the Benefits, What they Fear Most
A majority of older adults agree that all aged ≥65 years should be screened annually for dementia; more than half significantly fear a positive result, the National Poll on Healthy Aging reports.
Alzheimer Drug Lecanemab Granted Full FDA Approval
FDA's action, based on confirmatory evidence showing slowed disease progression, follows a January 2023 accelerated approval.
Daily Dose: Prediabetes, Intervening Diabetes, & Subsequent Dementia Risk
Your daily dose of clinical news you may have missed.
Younger Age at Diabetes Onset Associated with Higher Risk of Dementia, According to New Study
Results also showed that prediabetes is associated with dementia risk but this risk was explained by the subsequent development of diabetes.
FDA Approves Brexpiprazole for Agitation Associated with Alzheimer Dementia
Brexpiprazole, an atypical antipsychotic, is the first and only medication approved to treat AD-associated agitation, reported in almost half of people with the disease.
Donanemab Significantly Slows Cognitive, Functional Decline in Early Alzheimer Disease
Eli Lilly's investigational drug targeting amyloid plaque slowed clinical decline by 35% in participants with early symptomatic Alzheimer disease at 18 months, the company announced.
Daily Dose: Multisite Chronic Pain & Risk for Dementia, Cognitive Decline
Multisite Chronic Pain Increases Dementia Risk, Hippocampal Injury: UK Biobank Analysis
The risk of neurocognitive abnormality increased with each additional pain site among patients with multisite chronic pain and appeared to be mediated by loss of hippocampal volume.
Daily Dose: Stress & Cognitive Function among Older Adults
Perceived Stress Linked to Cognitive Impairment among Older Adults in the REGARDS Study
Screening for stress among older adults who present to primary care with signs of cognitive impairment could be key to reducing risk and targeting intervention, study authors say.
Daily Dose: Vaccine-preventable Viruses & Neurodegenerative Disease
Vaccine-preventable Viruses Associated with Increased Risk for Neurodegenerative Disease: NIH Findings
The large biobank-based study found 22 pairings of a neurodegenerative disorder and a previous viral infection. Vaccines exist against several of those viruses.
Dementia Risk in Older Women Reduced with More Vigorous Physical Activity, More Daily Steps
Accelerometer-measured physical activity and steps were associated with as much as a 60% lower risk of Alzheimer's disease and related dementias in a new study.
Cardiometabolic Diseases and Dementia Risk Show Dose-dependent Relationship in Large Twin Study
For each cardiometabolic disease, the risk of all-cause dementia rose by 42%; the risk rose 26% for Alzheimer disease and 64% for vascular dementia. Temporal onset and genetics play key roles.
Dementia: New Screening Tool to be Evaluated in Primary Care
The NIH has awarded $11 million for evaluation of a 5-minute, largely visual screening test for dementia intended for use in primary care practice.
Decreased Dementia Risk Associated with Increased Daily Step Count
A daily step count of as few as 3800 was associated with a 25% reduced risk of incident dementia in a cohort of 78 000 adults; the optimal count was fewer than 10 000.
Younger Age at Type 2 Diabetes Diagnosis in Adults Increases Risk for Poor Outcomes
A T2D diagnosis in adults aged 50 to 59 years vs 60 to 69 years or ≥70 years was linked to significantly increased risk for cardio- and cerebrovascular disease and all-cause mortality.
Dementia Risk May be Driven by Multimorbidity vs Single Risk Factors, Suggests a New Study
Multimorbidity was associated with a 63% increased risk for dementia among adults older than age 60 years followed for up to 15 years.
Risk of MCI Progression to Dementia Reduced with ARBs vs Other Hypertension Rx
A new study compared the differential effects of agents used to treat hypertension on the risk for dementia in patients with hypertension and mild cognitive impairment.
Intranasal Insulin Could Help Slow Age-related Cognitive Decline, Suggests a New Study
Treatment with intranasal insulin improved executive function and verbal memory, as well as other measures, in participants with and without type 2 diabetes.
Dementia, Falls Screening in Older Adults Increased in Primary Care with Clinician Education, EHR Enhancement
Screening of older adults for falls and cognitive impairment should be routine in primary care; a recent study highlights an intervention that could help.
Dabigatran and Warfarin Appear Similarly Protective Against Dementia
Patients taking either of the 2 anticoagulants showed no large differences on 4 cognitive test scores at 2 years, according to authors of the GIRAF trial.
Study: No Link Found between Statin Use and Cognitive Decline, Dementia in Older Adults
A new analysis of the large ASPREE trial found statin use in older adults is not associated in the incidence of dementia or a decline in neurocognitive health.
Study: Patients with Dementia at Higher Risk for COVID-19 Infection, but Not Death
International Stroke Conference: Adults with dementia are more likely to be infected with COVID-19, but no more likely to die from it vs those without cognitive impairment.
Cannabis and Cognition and HIV
It’s how much cannabis your patients with HIV infection smoke now-not over their lifetime-that appears to affect their cognition.
More Headache, Less Migraine With Dementia
An association was found between headache or non-migrainous headache and later dementia. Not so for migraine.
Impaired Blood Flow in Diabetic Brain Tied to Cognitive Problems
A multi-step inflammatory cascade appears to connect hyperglycemia and brain dysfunction.
Batting Averages and Sex Improvement
Here’s a look at what’s new and interesting on the Web for health care professionals.
The Obesity and Dementia Link
Growing evidence suggests a link between obesity and dementia, but risk may be heightened or lowered, depending on age. In this study, early to mid-life obesity was linked with increased risk of later dementia.
Stroke Prevention, Heart Disease and Women, and More
In the news: stroke prevention, heart disease and women, migraine and depression, cholinesterase inhibitors and dementia, multivitamins and cataract risk.
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