Dementia

A majority of older adults agree that all aged ≥65 years should be screened annually for dementia; more than half significantly fear a positive result, the National Poll on Healthy Aging reports.

FDA's action, based on confirmatory evidence showing slowed disease progression, follows a January 2023 accelerated approval.

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Results also showed that prediabetes is associated with dementia risk but this risk was explained by the subsequent development of diabetes.

Brexpiprazole, an atypical antipsychotic, is the first and only medication approved to treat AD-associated agitation, reported in almost half of people with the disease.

Eli Lilly's investigational drug targeting amyloid plaque slowed clinical decline by 35% in participants with early symptomatic Alzheimer disease at 18 months, the company announced.

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The risk of neurocognitive abnormality increased with each additional pain site among patients with multisite chronic pain and appeared to be mediated by loss of hippocampal volume.

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Screening for stress among older adults who present to primary care with signs of cognitive impairment could be key to reducing risk and targeting intervention, study authors say.

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The large biobank-based study found 22 pairings of a neurodegenerative disorder and a previous viral infection. Vaccines exist against several of those viruses.

Accelerometer-measured physical activity and steps were associated with as much as a 60% lower risk of Alzheimer's disease and related dementias in a new study.

For each cardiometabolic disease, the risk of all-cause dementia rose by 42%; the risk rose 26% for Alzheimer disease and 64% for vascular dementia. Temporal onset and genetics play key roles.

The NIH has awarded $11 million for evaluation of a 5-minute, largely visual screening test for dementia intended for use in primary care practice.

A daily step count of as few as 3800 was associated with a 25% reduced risk of incident dementia in a cohort of 78 000 adults; the optimal count was fewer than 10 000.

A T2D diagnosis in adults aged 50 to 59 years vs 60 to 69 years or ≥70 years was linked to significantly increased risk for cardio- and cerebrovascular disease and all-cause mortality.

Multimorbidity was associated with a 63% increased risk for dementia among adults older than age 60 years followed for up to 15 years.

A new study compared the differential effects of agents used to treat hypertension on the risk for dementia in patients with hypertension and mild cognitive impairment.

Treatment with intranasal insulin improved executive function and verbal memory, as well as other measures, in participants with and without type 2 diabetes.

Screening of older adults for falls and cognitive impairment should be routine in primary care; a recent study highlights an intervention that could help.

Patients taking either of the 2 anticoagulants showed no large differences on 4 cognitive test scores at 2 years, according to authors of the GIRAF trial.

A new analysis of the large ASPREE trial found statin use in older adults is not associated in the incidence of dementia or a decline in neurocognitive health.

International Stroke Conference: Adults with dementia are more likely to be infected with COVID-19, but no more likely to die from it vs those without cognitive impairment.

It’s how much cannabis your patients with HIV infection smoke now-not over their lifetime-that appears to affect their cognition.

An association was found between headache or non-migrainous headache and later dementia. Not so for migraine.

A multi-step inflammatory cascade appears to connect hyperglycemia and brain dysfunction.

Here’s a look at what’s new and interesting on the Web for health care professionals.

Growing evidence suggests a link between obesity and dementia, but risk may be heightened or lowered, depending on age. In this study, early to mid-life obesity was linked with increased risk of later dementia.

In the news: stroke prevention, heart disease and women, migraine and depression, cholinesterase inhibitors and dementia, multivitamins and cataract risk.