Inflammatory Bowel Disease

When does management of Crohn disease warrant assessment of C-reactive protein and fecal calprotectin and when is endoscopy indicated? Test your IBD IQ.

There is a lot of new information about the link between various malignancies and inflammatory bowel disease. Here: answers to 3 key questions.

Diet diaries and food frequency questionnaires are both effective tools to capture important patterns between food items and symptoms of IBD.

IDA is commonly seen in IBD as a result of iron malabsorption and, ironically, chronic blood loss through disrupted mucosal surfaces.

Patients with UC who also have celiac disease may be at higher risk for pancolitis as opposed to more limited forms of inflammatory bowel disease.

The mechanisms and effectiveness of probiotics in treatment of irritable bowel syndrome and inflammatory bowel disease are emerging.

New insights into how clinicians might approach treatment for patients with IBD highlighted the recent Crohn’s & Colitis Foundation’s Clinical & Research Conference.

New drugs are needed because a significant fraction of patients reach the end of the line with existing therapies.

All patients with IBD should receive aggressive ongoing assessment of their inflammatory state and its response to immunomodulators, anti-TNF drugs, and other agents.

A purely dichotomous understanding of whether to start treatment for patients who have IBD with anti-TNF agents is becoming an outdated view.

Even the most experienced and skilled gastroenterologists in the country are struggling to make science-based decisions in this area.

A straightforward discussion drove toward attendees toward the more current understanding of the clinical and genetic overlap between the 2 major forms of IBD.

They are similar chronic inflammatory diseases with causes unknown, and recent clinical and genetic evidence supports an intertwined pathogenic relationship.

Patients with ulcerative colitis and Crohn’s disease typically don’t receive preventive services at the same rate as general medical patients. Vaccination is a key area of confusion.

The location (pretibial surface) of this ulcer, its visibly rolled undermined border, and severe pain are all typical of pyoderma gangrenosum, which is typically associated with inflammatory bowel disease, rheumatoid arthritis, and hematologic malignancies.

Is the increased risk of IBD due to pollution, a too-clean home, or antibiotics? Or none of the above?

An association between non-steroidal anti-inflammatory drugs and these two inflammatory bowel disorders has long been suspected but not, until now, documented.

Patients with IBD may have discomfort for 3 to 5 years before a diagnosis is made. Many are treated unsuccessfully with antibiotics, anti-spasmodics, or narcotics. Here, read 5 important tips, plus a bonus point, to help streamline diagnosis and management.

Like other chronic inflammatory conditions, inflammatory bowel disease (IBD) has been revolutionized by the advent of biologic agents that fundamentally alter the inappropriate inflammatory response. The most potent of these are the biologic agents, infliximab, adalimumab, certolizumab pegol, and natalizumab. They also have the most dangerous side-effect profile.

Are persons with asthma at risk for other proinflammatory disorders? Yes, say researchers from the Mayo Clinic and Olmsted Medical Center in Rochester, Minn, who found that asthma is associated with the development of diabetes mellitus and coronary artery disease. However, there was no association between asthma and rheumatoid arthritis or inflammatory bowel disease.

A diet high in fats and protein increases the risk of developing ulcerative colitis and Crohn’s disease, researchers found. Hou and colleagues performed a systematic review to evaluate the association between diet and risk of inflammatory bowel disease (IBD)

Despite a lower prevalence of traditional risk factors-such as hypertension and diabetes-patients with inflammatory bowel disease (IBD) have a higher incidence of stroke, said researchers at the University of Miami.

Does upper endoscopy affect the diagnosis or management of adults with colitis? No, say investigators from Cedars-Sinai Medical Center in Los Angeles, although the procedure is routinely performed in children with inflammatory bowel disease (IBD) of the colon.

Quality of life in children and adolescents with inflammatory bowel disease (IBD) is a key focus of research presented at the 2010 Advances in IBD conference in Hollywood, Florida. Two of the top abstracts address social isolation and patient adherence to medication regimens among teenagers with IBD.

More than 1000 clinicians and researchers from all over the world will gather in Hollywood, Florida, this week for the 2010 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Conference. The featured speaker is Jean-Frederic Colombel, MD, Professor of Hepatogastroenterology at Centre Hospitalier Universitaire de Lille, France, who will discuss management strategies to improve the quality of care of patients with IBD.

Certain patients with inflammatory bowel disease are at heightened risk for the development of colorectal cancer. But researchers have not yet been able to discover markers that can identify these patients.

In this engaging session, 5 patients with complex and difficult cases of ulcerative colitis were presented to an expert panel, which consisted of Maria Abreu, MD, Edward Loftus, MD, and David Rubin, MD. The panel moderator was Jean-Paul Achkar, MD.

A 19-year-old woman presented with shortness of breath, dry cough, and pleuritic chest pain of unknown duration. Her medical history included endometriosis, a benign ovarian cyst,

A 35-year-old woman presented to the emergency department (ED) with vague abdominal complaints. The patient had a complex medical history that included diverticulosis and relapsing polychondritis. Initially, her polychondritis was limited to involvement of the ears and nose. Within the past few years, however, her polychondritis flares had been associated with progressive dyspnea, which prompted intermittent and then long-term use of high-dose oral corticosteroids.

Traveler's diarrhea (TD) occurs in persons traveling fromindustrialized countries to less developed regions of the world.Because of the growing ease of travel and an increasinglyglobalized economy, TD is becoming more common. Increasingantibiotic resistance among causative bacterial organisms andalso emergence of new pathogens are additional challenges inthe management of TD. Enterotoxigenic and enteroaggregativepathotypes of Escherichia coli are the principal causes of TD.This review discusses the epidemiology of these pathogens, aswell as elements of prevention, diagnosis, and management.[Infect Med. 2008;25:264-276]