Headache and Migraine

In episodic migraine, both traditional oral OTC medications and newly approved classes led to significantly better improvements in pain compared with placebo.

Fatigue was positively correlated with frequency, duration, severity and chronicity of migraine episodes and more common among chronic migraineurs, a new study reveals.

The device from Nexalin Technology outperformed placebo on key measures of pain relief, sleep quality, anxiety, and quality of life.

An overview of oral preventive medication options for migraine for primary care clinicians, here.

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The oral gepant reduced monthly migraine days as well as mean monthly use of migraine rescue medication.

Is BMI or body fat a better estimate of obesity?; spoiler: older women do drink ETOH; USPSTF vs ACC/AHA; plus no more opioids for LBP and a primer on migraine meds.

An overview of common headache conditions and treatments for primary care clinicians, here.

Menstrual migraine is often described as more disabling than non-menstrual migraine. Get an overview and test your knowledge, here.

The role of the trigeminal nerve and its connection to the brainstem has led to a greater understanding of where migraine pain originates. Expert explains, here.

Migraine disproportionately affects women, a disparity typically ascribed to hormonal differences. A new study takes a new look at the issue.

Cluster headache and migraine are described as "highly circadian at multiple levels," suggesting hypothalamus involvement and potential for new treatments, study authors say.

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Among women with prepregnancy migraine diagnosis, rates of gestational hypertension and preeclampsia were 28% and 40% higher, respectively, vs women without migraine.

Your daily dose of clinical news you may have missed.

In a study of 874 adults, more women were diagnosed with chronic cluster headache and experienced longer attacks compared with men.

Headache is a common complaint in primary care--and sometimes it presents full-blown. You can rescue the patient in distress by keeping 5 common injectables on hand. 

Individuals with migraine were found more likely to have IBS and IBS was more prevalent in those with migraine; both associations were statistically significant.

Findings for atogepant from the phase 3 PROGRESS study will form the basis of a submission by AbbVie to FDA for a label expansion in the US.

Lifetime use of opioids for migraine was found to be higher than for triptan medications. Try these 10 questions on other OVERCOME findings.

Findings on use of acute and preventive migraine therapy continue to reveal gaps with far more patients eligible than the proportions using either type.

When choosing a migraine treatment for acute attack relief, the American Headache Society suggests following these steps.

Researchers also found that women with migraine with aura had a higher risk of preeclampsia than those with migraine without aura.

Intranasal CGRP inhibitor zavegepant met coprimary regulatory endpoints in pivotal phase 3 trial in adults with migraine; FDA submission planned for Q1 2022.

Five migraine management essentials for PCPs and headache patients are summarized with the mnemonic SEEDS. 

The daily oral CGRP inhibitor is the only agent in the class developed specifically for prevention vs acute treatment of episodic migraine.

The DHE nasal spray delivered pain relief at 2 hours for 66% of patients; 93% of those remained pain-free at 24 hours and 86% at 2 days post-dose.

Oral CGRP inhibitor atogepant significantly reduced monthly headache days and improved daily function in adults with 4 to 14 headaches per month.

A woman in her 50s who has a history of tension headache presents to the ED with a headache different from any she has had. Mild photophobia is the only finding on physical exam. Your dx?

Early diagnosis of cluster headache, commonly considered the most painful condition on earth, is essential to curbing disability; here's what primary care clinicians need to know.