Androgen receptor gene

December 28, 2011

1.  Giovannucci E, Stampfer MJ, Krithivas K, et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 1997;94(7):3320-3323

Androgen receptor gene (AR)

Stimulated by testosterone. Acts inside prostate to stimulate cell growth. See biological pathway map for further information.

 

Condition or outcome:  Prostate cancer

Variable:  Number of CAG repeats in gene (<18 vs >26)

Total of sample sizes in highly cited research:1  1182

Relative risk in highly cited research:  1.23

Relative risk in meta-analysis:2  1.19

 

Further information from NIH gene database:  OMIM entry 313700

1.  Giovannucci E, Stampfer MJ, Krithivas K, et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 1997;94(7):3320-3323

2. Edwards SM, Badzioch MD, Minter R, et al. Androgen receptor polymorphisms. Int J Cancer. 1999; 84(5):458-465.