Conditions Associated With Proton Pump Inhibitor Use

August 15, 2013

Proton pump inhibitors have been associated with magnesium deficiency, pneumonia, and Clostridium difficile infection.

All of the following have been associated with long-term proton pump inhibitor use except . . . ?

A. Magnesium deficiency
B. Pneumonia
C. Clostridium difficile
D. Gastric cancer

Correct answer: D

Proton pump inhibitors (PPIs) have been associated with magnesium deficiency, pneumonia, and Clostridium difficile infection. Although PPIs increase gastrin levels, which can lead to enterochormaffin-like cells hyperplasia, there has been no association between PPI use and gastric carcinoids or other cancers.