Hypersensitivity Reactions to ARBs: How Common?

April 1, 2007

Among patients in whom angioedema developed while they were being treated with an ARB, 50% had previously had a similar reaction to angiotensin-converting enzyme (ACE) inhibitors, according to one report.

 

Angioedema developed in a white male patient who was taking an angiotensin-receptor blocker (ARB). How frequent is such a reaction?

- MD

Among patients in whom angioedema developed while they were being treated with an ARB, 50% had previously had a similar reaction to angiotensin-converting enzyme (ACE) inhibitors, according to one report.1 The overall frequency of angioedema with ACE inhibitors is very low; however, it is important not to prescribe ARBs for patients who have a history of angioedema in reaction to ACE inhibitors.

- Reza Abdi, MD
  Instructor in Medicine  
  Harvard Medical School  
  Cambridge, Mass

References:

REFERENCE:1. Van Rinjnsoever EW, Kwee-Zuiderwijk WJM, Feenstra J. Angioneurotic edema attributed to the use of losartan. Arch Intern Med. 1998;158:2063-2065.