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Lentigo Maligna Melanoma, In Situ
The development of eccentric pigmentation within a previously stable pigmented lesion may indicate malignant degeneration, as was the case here. Of all melanomas, lentigo maligna melanoma has the best overall prognosis.
An 82-year-old man complained about an asymptomatic “spot” on his chest within which a darker area had recently developed.
Key point: Physical examination revealed a large pigmented macule on the right upper chest. A darker area was eccentrically placed within the larger lesion. A biopsy revealed lentigo maligna melanoma, in situ.
Treatment: The lesion was removed by simple excision with a 5-mm border of normal skin.
Note: The development of eccentric pigmentation within a heretofore stable pigmented lesion may indicate malignant degeneration. There is some debate about the optimal border of normal skin to remove, with proponents of anywhere from several millimeters to nearly a centimeter. Lentigo maligna melanoma has the best overall prognosis among all types of melanomas.
Biden Administration Announces First 10 Prescription Drugs Slated for Price Negotiations
August 29th 2023The first 10 drugs identified for negotiations under the Inflation Reduction Act include several well advertised agents indicated to treat diabetes, heart failure, and other chronic diseases.
