Lentigo Maligna Melanoma, In Situ
The development of eccentric pigmentation within a previously stable pigmented lesion may indicate malignant degeneration, as was the case here. Of all melanomas, lentigo maligna melanoma has the best overall prognosis.
An 82-year-old man complained about an asymptomatic “spot” on his chest within which a darker area had recently developed.
Key point: Physical examination revealed a large pigmented macule on the right upper chest. A darker area was eccentrically placed within the larger lesion. A biopsy revealed lentigo maligna melanoma, in situ.
Treatment: The lesion was removed by simple excision with a 5-mm border of normal skin.
Note: The development of eccentric pigmentation within a heretofore stable pigmented lesion may indicate malignant degeneration. There is some debate about the optimal border of normal skin to remove, with proponents of anywhere from several millimeters to nearly a centimeter. Lentigo maligna melanoma has the best overall prognosis among all types of melanomas.
Lebrikizumab Demonstrates Efficacy, Safety in Patients With Skin of Color With AD
June 11th 2025RAD 2025. Lebrikizumab improved skin clearance, itch, and pigmentation in patients with skin of color and atopic dermatitis, with strong safety data through 24 weeks, according to late-breaking data.
