Proton Pump Inhibitors Linked to Cognitive Decline

June 21, 2016

In this Medical News Minute, Dr Bobby Lazzara looks at the impact of PPI use on incident dementia in the elderly.

In this Medical News Minute, developed exclusively for Consultantlive.com, Dr Bobby Lazzara reviews a large prospective cohort study (<70 000 participants) that analyzed the relationship between use of proton pump inhibitors (PPIs) and incident dementia. Participants were age 75 years or older and had no disease at baseline. After adjusting for potential confounding factors (ie, age, sex, comorbidities, polypharmacy) subjects who regularly used PPIs had a significantly increased risk of incident dementia vs those who did not use them (P <.001). 

Use of PPIs in murine models has been shown to increase β-amyloid deposits in brain tissue; the authors suggest that avoiding PPI use may be one way to help reduce risk of cognitive decline in the elderly.

Source: Gomm W, von Holt K, Thomé F, et al. Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurol. 2016 Apr 1;73:410-416. doi: 10.1001/jamaneurol.2015.4791.