DPP-4 Antagonists: Benefits, Risks, and the FutureByPayal Kohli, MD,Darren K. Mcguire, MDFebruary 26th 2013Dipeptidyl peptidase-4 inhibitors, of the incretin class of antidiabetes drugs, are weight neutral, avoid hypoglycemia, and result in an average reduction in HbA1c of 0.5% to 1.0%