Norman Levine, MD

This patient with long-standing insulin-dependent diabetes has difficultyclosing his hand because of “tight skin.” Diabetes is the cause: this findingoccurs more often in persons with microvascular complications, such asretinopathy and nephropathy. The condition may occur even in patients withwell-controlled diabetes.

Numerous brown spots on his leg brought this man with long-standing diabetes mellitus to his physician. He thought the spots were related to trauma.

This patient with long-standing insulin-dependent diabetes mellitus has difficulty in closing his hand because the skin is "very tight."

Numerous brown spots on the leg of a man with longstandingdiabetes are diabetic dermopathy. This is amicroangiopathy of the small arterioles of the legs, whichresults in atrophic brown papules.

This patient has a 2-year history of red plaque with a yellow atrophic center on the leg, which has ulcerated over the past 3 months.

These velvety, hyperpigmented plaques are secondary to acanthosis nigricans, a common problem in patients with insulin-resistant states.

Hundreds of yellow papules developed on the trunk and extremities of this patient, whose diabetes was uncontrolled.